Using Holographic 3D Imaging to Observe Virus-Induced Cytopathic Effects
Cytopathic effects (CPEs) are a hallmark of infection. Due to the phototoxicity of classical optical microscopy, CPEs are difficult to observe. This study reports different patterns of viral infection in live cells using Digital HoloTomographic Microscopy (DHTM). DHTM is label-free and records the phase shift of low-energy light passing through the sample on a transparent … Read more