1 Introduction Antibody-drug conjugates (ADC) are an emerging technology that selectively targets cancer cells to overcome the limitations of chemotherapy.ADC binds to antigens, especially those overexpressed on the surface of cancer cells, reducing side effects caused by nonspecific targeting and improving the therapeutic index. The idealADC efficacy relies entirely on several physicochemical factors, such as … Read more
Introduction ADC drugs are a class of highly promising anti-tumor drugs that are rapidly developing. Although 14 ADCs have been officially approved, the complex structure of ADCs poses significant challenges in the development and optimization of new ADC drugs. Studying the “structure-activity relationship” of ADC drugs and understanding the intrinsic connection between the efficacy/safety of … Read more
Introduction Antibody-drug conjugate (ADC) therapy has rapidly developed over the past few decades, with 14 products approved globally and over 140 ADCs currently in clinical trials. By 2030, the ADC market is expected to exceed $15 billion. The basic principle of ADCs: by combining the specificity of monoclonal antibodies with the cytotoxicity of effective small … Read more
Source: Beike Society Antibody-drug conjugates (ADCs) have become a popular avenue in tumor treatment in recent years, typically covalently linking a monoclonal antibody (mAb) to a cytotoxic drug (payload) via a chemically synthesized linker. ADCs combine the advantages of highly specific targeting capabilities with potent killing effects, achieving precise and efficient elimination of cancer cells. … Read more
This conference is themed “Innovative Processes, Achieving the Future of the Pharmaceutical Industry,” featuring one keynote session and three parallel sessions, gathering over 50 professional speakers from the fields of antibodies, ADCs, GLP-1, and peptides. It focuses on downstream processes and advanced separation and purification techniques, discussing the future of the pharmaceutical industry! Known as … Read more
Background The core algorithm of the product I have been researching these days is the phase difference detection of the sine signals transmitted and received. On the STM32F407 processor, high-speed sampling of the received and transmitted signals is performed through DMA+SPI communication. An algorithm is designed to calculate the phase difference between the received and … Read more
Zha Tianyi1, Chen Shengqi2, Ge Junyao3 (1. Changshu High School, Jiangsu Suzhou 215500; 2. Department of Electrical Engineering and Applied Electronic Technology, Tsinghua University, Beijing 100084; 3. School of Communication and Information Engineering, Nanjing University of Posts and Telecommunications, Jiangsu Nanjing 210023) Abstract: This paper adopts the fractional-N phase-locked loop (PLL) chip ADF4351 as the … Read more
Abstract:Gastric cancer is a refractory malignant tumor, ranking fifth in incidence and third in mortality worldwide. Despite various treatment options significantly improving the prognosis of advanced gastric cancer (AGC), survival rates remain unsatisfactory. Therefore, the development of new therapeutic drugs is crucial for enhancing long-term efficacy. Antibody-drug conjugates (ADCs) are innovative and effective anti-tumor drugs … Read more
PCBA (Printed Circuit Board Assembly) refers to the process of mounting electronic components on a printed circuit board (PCB) to form a complete electronic product.PCBA is fundamental to the electronics industry, as nearly all electronic devices are composed of PCBA. The quality and performance of PCBA directly affect the lifespan, speed, stability, and reliability of … Read more
Author｜Wenxin Small molecule cytotoxins serve as the “warheads” for ADCs and are crucial components in killing tumor cells. Although there are numerous toxins derived from natural products and chemical synthesis, only a small fraction can be used as cytotoxins in ADCs. The reason is that ADCs have high requirements for toxins, which typically must meet … Read more