Understanding ADC Drugs: A Visual Guide

Understanding ADC Drugs: A Visual Guide

ADC In the era following chemotherapy, targeted therapy, and immunotherapy, ADC drugs, which combine cytotoxic drugs with targeted monoclonal antibodies, have opened a new era of fourth-line cancer treatment with exceptional results. They have become a significant class of new drugs in cancer treatment both domestically and internationally. So, what are ADC drugs (antibody-drug conjugates)? … Read more

Overview of ADC Drug Development Landscape

Overview of ADC Drug Development Landscape

Antibody-drug conjugates (ADC) are also known as “biological missiles”. They connect cytotoxic drugs similar to chemotherapy with monoclonal antibodies, consisting of three parts: antibodies, linkers, and payloads (small molecule cytotoxic drugs). This combination achieves the dual advantages of small molecules and antibody drugs, enabling targeted killing of tumors and other diseases. In recent years, global … Read more

Next Generation Antibody-Drug Conjugates (ADCs): What They Look Like

Next Generation Antibody-Drug Conjugates (ADCs): What They Look Like

Antibody-drug conjugates (ADCs) have become an important treatment method in the field of oncology, offering superior clinical characteristics compared to chemotherapy. However, the application of ADCs still faces two significant challenges. First, there are very few validated payloads with proven mechanisms of action (MoA), which limits the expansion of indications. Approved ADC payloads cover three … Read more

Physicochemical Analysis and Structural Characterization of Antibody-Drug Conjugates (ADCs)

Physicochemical Analysis and Structural Characterization of Antibody-Drug Conjugates (ADCs)

Preface Preface Author Cloud Assistant Antibody-drug conjugates (ADCs) are a class of emerging drugs that combine the advantages of both antibodies and small molecule toxins. Compared to traditional cytotoxic drugs, ADCs have the advantages of strong targeting and fewer side effects, making them promising in the field of tumor therapy. To date, 11 ADC drugs … Read more

Combination Therapy of Antibody-Drug Conjugates (ADCs)

Combination Therapy of Antibody-Drug Conjugates (ADCs)

Introduction Antibody-drug conjugates (ADCs) are formed by linking monoclonal antibodies that target specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs.ADCs consist of three main components: the antibody responsible for selectively recognizing cancer cell surface antigens, the … Read more

Understanding ADC Types and Quantization Mechanisms

Understanding ADC Types and Quantization Mechanisms

An Analog-to-Digital Converter (ADC) is primarily used to convert continuously transmitted analog signals into digital signals, facilitating rapid processing and analysis of transmitted information by digital systems (such as CPUs and MCUs). Generally speaking, the different quantization mechanisms of ADCs are one of the key factors determining the complexity and performance of ADC design, as … Read more

Understanding Antibody-Drug Conjugates (ADC)

Understanding Antibody-Drug Conjugates (ADC)

Introduction Antibody-drug conjugates (ADCs) typically consist of: highly specific and high-affinity antibodies, stable linkers, and potent small-molecule cytotoxic drugs1. The key to the development of ADCs lies in the selection of targets, antibodies, cytotoxic payloads, linkers, and the conjugation method. Among these, the conjugation method of ADCs directly determines the drug-to-antibody ratio (DAR), the distribution … Read more

Introduction to Antibody-Drug Conjugates (ADCs)

Introduction to Antibody-Drug Conjugates (ADCs)

Antibody-drug conjugates (ADCs) are formed by linking monoclonal antibodies (mAbs) with small molecule drugs through linkers. The specificity of mAbs for tumor cells allows small molecule drugs to act effectively within tumor tissues, significantly reducing the high toxicity and side effects of traditional small molecule drugs while improving overall therapeutic efficiency. Currently, there are 13 … Read more

How to Use ADCs? Managing Adverse Reactions? Expert Recommendations

How to Use ADCs? Managing Adverse Reactions? Expert Recommendations

*For reference by medical professionals only Antibody-drug conjugates (ADCs) have become a new hotspot in the field of anti-tumor therapy, with explorations in the treatment of breast cancer, lung cancer, gastric cancer, colorectal cancer, and other types of cancer. With the approval and clinical entry of drugs such as Trastuzumab Deruxtecan, Ado-trastuzumab emtansine, and Enfortumab … Read more

Innovative Applications of ADC Technology Beyond Oncology

Innovative Applications of ADC Technology Beyond Oncology

Since 2000, the ADC field has gradually started to be pushed to market, and in recent years, it has emerged rapidly in the field of cancer treatment, leading to intense competition. To differentiate themselves, some companies are beginning to develop ADCs for non-oncology areas. Although the number of related ADCs is extremely limited and most … Read more