Cysteine

Late-Stage Aromatic C–H Bond Functionalization for Cysteine/Selenocysteine Bioconjugation

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Late-Stage Aromatic C–H Bond Functionalization for Cysteine/Selenocysteine Bioconjugation

Hello everyone, this week I am sharing an article published in JACS titled “Late-Stage Aromatic C–H Bond Functionalization for Cysteine/Selenocysteine Bioconjugation.” The corresponding authors are Professor Wang Binju from Xiamen University, Dr. Daphna Shimon from Hebrew University, and Professor Norman Metanis. Professor Wang’s research focuses on multiscale theoretical simulations of chemical reactions in aqueous solutions … Read more

Understanding Antibody-Drug Conjugates (ADC)

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Understanding Antibody-Drug Conjugates (ADC)

Introduction Antibody-drug conjugates (ADCs) typically consist of: highly specific and high-affinity antibodies, stable linkers, and potent small-molecule cytotoxic drugs1. The key to the development of ADCs lies in the selection of targets, antibodies, cytotoxic payloads, linkers, and the conjugation method. Among these, the conjugation method of ADCs directly determines the drug-to-antibody ratio (DAR), the distribution … Read more