Antibody-drug conjugates (ADC) are formed by linking monoclonal antibodies that target specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. Since the first ADC (Gemtuzumab-ozogamicin, trade name: Mylotarg) was approved for the treatment of CD33-positive acute myeloid … Read more
What Is ADC? Antibody-drug conjugates (ADC) are a new type of targeted therapeutic drug, composed of monoclonal antibodies that specifically target antigens linked to small molecule cytotoxic drugs via linkers. They combine the powerful killing effect of traditional small molecule chemotherapy with the tumor-targeting capability of antibody drugs. This structure allowsADC to deliver drugs directly … Read more
During the progression of cancer, solid tumors often grow in areas lacking nutrients and oxygen. The abnormal structure of blood vessels and the high growth rate of tumors lead to cells that are far from blood vessels being in a state of hypoxia or low oxygen levels. The hypoxic environment within tumors reduces the efficacy … Read more
Written by丨Wang Cong Edited by丨Wang Duoyu Typeset by丨Shui Chengwen Bacteria are attracted to chemical gradients, such as low oxygen levels or high acidity, both of which are commonly found near tumor tissues. Injecting bacteria near tumor tissues for cancer treatment is known as bacteria-mediated tumor therapy. The bacteria accumulate in the tumor tissue and grow, … Read more
Sperm, bacteria, bubbles, and bioastronauts are set to become the latest microbots developed for human use in cancer treatment over the coming years. Microscopic robots rolling through blood vessels, drilling into the brain, and swimming in the intestines are no longer scenes from science fiction movies. Scientists and engineers are developing microbots, ranging from the … Read more
Reading Abstract A team of scientists in Singapore has developed a micro-sized intelligent robot, the size of a grain of rice, controlled by a micro-magnetic field, capable of targeted drug delivery within the body. This micro soft robot is made from non-toxic intelligent magnetic composite materials, highly flexible, and can “navigate” through complex environments in … Read more
Professor Yu Zhiqiang from Southern Medical University and Researcher Tang Longguang from Zhejiang University published a research paper titled “pH-activated nanoplatform for visualized photodynamic and ferroptosis synergistic therapy of tumors” in the international academic journal Journal of Controlled Release (IF=11.467). Compared to traditional chemotherapy, photodynamic therapy (PDT) can effectively reduce side effects and prevent drug … Read more
Piezoelectric Dynamic Therapy (PzDT) is a tumor treatment method that utilizes mechanical energy to trigger the polarization of piezoelectric materials. Under the action of ultrasound (US), the immense pressure generated by the collapse of cavitation bubbles serves as a mechanical force source for the piezoelectric sonosensitizer, showing feasible potential. An internal electric field can form … Read more
Sonodynamic therapy (SDT) is a non-invasive treatment method based on reactive oxygen species (ROS) that interacts with ultrasound (US) activated sonosensitizers and surrounding oxygen and water molecules to produce highly cytotoxic ROS and induce apoptosis. Due to its ability to penetrate deep tissues while causing minimal damage to normal cells, it has significant potential in … Read more
iNature The photodynamic therapy (PDT) using oxygen-dependent type II photosensitizers is often limited by the hypoxic microenvironment of solid tumors. Type I photosensitizers generate oxygen-independent reactive oxygen species (ROS) under light irradiation, but they suffer from aggregation-caused quenching (ACQ) and low ROS generation efficiency. On December 19, 2024, the team led by Ge Zhishen from … Read more