gut microbiota

Research on the Mechanism of PCB138-Induced Metabolic-Related Fatty Liver Disease and Intervention with Theabrownin by the Team of Professor Zuo Zhenghong and Professor He Chengyong from Xiamen University

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Research on the Mechanism of PCB138-Induced Metabolic-Related Fatty Liver Disease and Intervention with Theabrownin by the Team of Professor Zuo Zhenghong and Professor He Chengyong from Xiamen University

Article Information First Authors: Han Jianrong, Liu Changqian, Chen Zhiyuan Corresponding Authors: Professor Zuo Zhenghong, Professor He Chengyong Affiliation: Xiamen University https://doi.org/10.1016/j.envint.2025.109780 Highlights • Previous studies on the toxicity of polychlorinated biphenyls (PCBs) primarily focused on high-dose acute exposure, which cannot simulate the actual exposure duration and methods in humans, presenting significant limitations. This study … Read more

Literature Sharing | J AM CHEM SOC | Probiotic-Drug Conjugates Achieve Site-Specific Probiotic Colonization and On-Demand Drug Release to Combat Ulcerative Colitis and Its Complications

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Literature Sharing | J AM CHEM SOC | Probiotic-Drug Conjugates Achieve Site-Specific Probiotic Colonization and On-Demand Drug Release to Combat Ulcerative Colitis and Its Complications

1. Research Background Ulcerative colitis (UC) is a chronic intestinal disease that severely affects the quality of life of patients and significantly increases the risk of colorectal cancer (CAC) associated with colitis, posing a major threat to patient survival. Current treatment strategies for UC are limited by single therapeutic mechanisms, uncontrolled drug release, and non-specific … Read more

Sepsis-Related Acute Kidney Injury Based on the Gut-Kidney Axis

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Sepsis-Related Acute Kidney Injury Based on the Gut-Kidney Axis

Sepsis-Related Acute Kidney Injury Based on the Gut-Kidney Axis Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection[1,2]. The most common manifestation is multiple organ dysfunction, particularly renal dysfunction, known as sepsis-associated acute kidney injury (SA-AKI)[3]. SA-AKI is common in patients with severe sepsis, with an incidence of … Read more

National Health Commission Approves HMOs for Various Infant Formulas: Exploring Nutritional Benefits for Children with Milk Allergy from Breast Milk Oligosaccharide Research

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National Health Commission Approves HMOs for Various Infant Formulas: Exploring Nutritional Benefits for Children with Milk Allergy from Breast Milk Oligosaccharide Research

*For medical professionals only On October 7, the official website of the National Health Commission announced that 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT), two human milk oligosaccharides (HMOs), have been officially approved for use as food nutritional fortifiers in infant formulas, follow-on formulas for older infants and toddlers, and special medical purpose infant formulas. HMOs are … Read more

Triple-Functional Probiotics with Intracellularly Synthesized Selenium Nanoparticles for Colitis Therapy by Regulating the Macrophage Phenotype and Modulating Gut Microbiota

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Triple-Functional Probiotics with Intracellularly Synthesized Selenium Nanoparticles for Colitis Therapy by Regulating the Macrophage Phenotype and Modulating Gut Microbiota

Click the blue text to follow us!Abstract Macrophage phenotype dysregulation is a major cause of colitis, as it not only enhances oxidative stress and exacerbates inflammatory responses but is also closely related to dysbiosis of the gut microbiota. To effectively treat colitis, it is necessary to address these three issues simultaneously, but current treatments are … Read more