E3 ligase

The Future of PROTACs and Molecular Glue: E3 Ligand Development Overview

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The Future of PROTACs and Molecular Glue: E3 Ligand Development Overview

This article combines literature and patents to introduce the recent development status of new E3 ligands. First, let’s talk about DCAF1. Biological Background of DCAF1 DCAF1 (also known as VprBP) is a multifunctional E3 ubiquitin ligase substrate receptor that participates in the regulation of various cellular processes. It is part of the Cullin-RING ligase (CRL) … Read more

DAC: Degrader-Antibody Conjugates and Their Mechanisms

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DAC: Degrader-Antibody Conjugates and Their Mechanisms

Introduction Degrader-antibody conjugates (DAC) are a novel entity that combines the payload of a proteolysis-targeting chimera (PROTAC) with monoclonal antibodies through a type of chemical linker (DAC = PROTAC + ADC). This article collects several examples of DAC from scientific and patent literature and records specific challenges associated with DAC construction. Overall, these examples indicate … Read more