Following the era of chemotherapy, targeted therapy, and immunotherapy, cytotoxic drugs conjugated with targeted monoclonal antibodies have opened a new era in tumor treatment with the ADC drug class, achieving remarkable results. They have now become a significant category of new drugs in cancer treatment both domestically and internationally.
So what exactly are ADC drugs? This article will explain in detail.
1. The Birth of ADC Drugs
2. Components of ADC Drugs — Three Elements
3. Mechanism of Action of ADC Drugs
Researchers have found that certain tumors contain a special type of cancer cells, such as those that overexpress human epidermal growth factor receptors 2 or 3 (HER2/HER3), TROP2, etc. These cancer cells spread and grow faster than other cancer cells. Today, we will take HER2 as an example to examine the mechanism of ADC drugs:
Currently, ADC drugs have shown excellent clinical efficacy in breast cancer, gastric cancer, urothelial carcinoma, lung cancer, and hematological malignancies, giving us hope for a new wave of drug breakthroughs by innovatively combining drug properties that were previously deemed ‘useless’ targets, leading to new hope and a new dawn!
Source | Medical Vision, Pharmaceutical Overview
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