Welcome to reprint, please note the source “Jiangcheng ITP Home”🎉🎉🎉 Decitabine (DAC) is commonly known as an anticancer drug, clinically used for the treatment of myelodysplastic syndromes (MDS), acute myeloid leukemia, chronic myelomonocytic leukemia, and other malignant hematological diseases,because it has demethylation and cytotoxic effects, which can induce cell death. However, its “magical” efficacy in … Read more
In the previous article where Little Lion discussed the selection of external sound cards, some friends in the comments mentioned that many DAC headphone amplifiers are actually excellent external sound cards that work perfectly with computers for audio playback. This headphone amplifier is commonly referred to as such; however, it should more accurately be called … Read more
What is a DAC? DAC stands for digital-to-analog converter. It is one of the audio devices that takes digital signals as input and outputs analog signals. Nowadays, many popular audio devices produce digital signals, such as smartphones, laptops, and many A/V receivers. The problem is that many audio devices that allow us to hear these … Read more
CCTC® Click the blue text above to follow Brief Overview: Direct Air Capture (DAC) Technology Introduction Source: Gas Exchange “Huaxia Climate welcomes business/ manuscripts/ advertising cooperation Direct Air Capture (DAC) is a carbon reduction technology that involves pulling air from the atmosphere and using chemical reactions to separate carbon dioxide gas. The captured carbon dioxide … Read more
Recently, ADC (Antibody-Drug Conjugate) conferences have been held one after another, with major biotech companies competing to report their ADC pipelines. It is expected that 2024 will still be the main venue for ADCs. Developing an entry-level ADC seems not difficult, but evaluating the pharmacology and toxicology in the preclinical stage has become a top … Read more
Currently, there are 15 ADC drugs approved globally, among which 6 ADC drugs have been approved in China, namely Trastuzumab emtansine, Brentuximab vedotin, Trastuzumab deruxtecan, Vidofludimus, Gemtuzumab ozogamicin, and Sacituzumab govitecan. This article provides a brief summary based on the currently approved ADC drugs worldwide, the types of tumors they are suitable for, and how … Read more
1. Mechanism of ADC Action Antibody-drug conjugates (ADC) (Click to enter the database to search for global ADC drug information) enter the body, the antibody part binds to the targeted antigen on the surface of tumor cells, tumor cells will endocytose the ADC molecule. Among them, some can bind to Fc receptors in the endosome, … Read more
In the early 20th century, Paul Ehrlich first proposed the famous “magic bullet” theory, suggesting that drugs could be developed to specifically target pathogenic structures without harming normal tissues and cells. Subsequently, the concept of antibody-drug conjugates (ADCs) was introduced, combining the target specificity of monoclonal antibodies with the anti-tumor properties of cytotoxic molecules. After … Read more
ADCs (Antibody-Drug Conjugates) and RDCs (Radionuclide Conjugates) are innovative drugs that have gained significant attention in recent years, demonstrating enormous potential in the field of oncology. They are referred to as the “magic bullets” of tumor-targeted therapy because they enable precise treatment while avoiding damage to normal cells. ADC drugs link antibodies with known effective … Read more
As of now, the toxicity and prevention measures of ADC in solid tumors are known as follows: â‘ The indications for ADCs are rapidly expanding, gradually shifting from late-stage to early-stage, and from single therapy to combination strategies. â‘¡ The toxicity characteristics of most ADCs are similar to the cytotoxicity of their payloads. â‘¢ Certain … Read more