Differences in Classification of TP53-MDS, MDS/AML, and AML by WHO and ICC

Differences in Classification of TP53-MDS, MDS/AML, and AML by WHO and ICC

Image Source: Xiao W, Nardi V, Stein E, Hasserjian RP. A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC. J Hematol Oncol. 2024;17(1):56. Published 2024 Jul 29. For TP53 positive MDS, MDS/AML, and AML, the requirements for TP53 mutations differ, leading to the discrepancies in classifications of TP53 positive … Read more

Classification of ICC Pediatric Refractory Cytopenia and MDS

Classification of ICC Pediatric Refractory Cytopenia and MDS

Original Authors: Rudelius M, Weinberg OK, Niemeyer CM, Shimamura A, Calvo KR. Background/Introduction ICC classifies pediatric myelodysplastic syndromes (MDS) separately from adult MDS. This separation acknowledges the unique biological characteristics of pediatric and adolescent MDS, which differ significantly from those of elderly MDS in terms of genetic landscape and treatment approaches. Pediatric MDS lacks recurrent … Read more

Introduction to Decitabine (DAC)

Introduction to Decitabine (DAC)

Welcome to reprint, please note the source “Jiangcheng ITP Home”🎉🎉🎉 Decitabine (DAC) is commonly known as an anticancer drug, clinically used for the treatment of myelodysplastic syndromes (MDS), acute myeloid leukemia, chronic myelomonocytic leukemia, and other malignant hematological diseases,because it has demethylation and cytotoxic effects, which can induce cell death. However, its “magical” efficacy in … Read more