Endocytosis

Overview of Non-Targeted Uptake and Toxicity Mechanisms of ADC Drugs

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Overview of Non-Targeted Uptake and Toxicity Mechanisms of ADC Drugs

Source: YaoDu Author: Cheng Chuan Yuan Hang Editor: Wan Zi 1 Introduction Antibody-Drug Conjugates (ADCs) are a novel class of highly effective biopharmaceuticals that link antibodies (Antibody) to biologically active small-molecule cytotoxic payloads (Payload) via linkers (Linker). ADCs aim to enhance the therapeutic index (TI) of chemotherapeutic agents by more selectively delivering cytotoxic drugs to … Read more

Endocytosis Mechanism of ADC Drugs

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Endocytosis Mechanism of ADC Drugs

Introduction In addition to the need for ADCs to target antigens that are overexpressed in tumors, another important factor is the efficiency of endocytosis, which is necessary for the release of the drug’s active payload. In fact, the efficacy of ADCs depends on the efficiency of targeted-mediated internalization to deliver effective payloads within tumor cells. … Read more

Mechanisms of Endocytosis for ADC Drugs

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Mechanisms of Endocytosis for ADC Drugs

▲ Click the image for details PREFACE Introduction For Antibody-Drug Conjugates (ADCs), the selection of drug targets not only requires overexpression in tumors but also depends significantly on the efficiency of endocytosis, which is essential for drug release activity. In fact, the efficacy of ADCs relies on the efficiency of targeted-mediated internalization for delivering effective … Read more