Discussion on Off-Target Toxicity Mechanisms of ADC Drugs
ADC drugs utilize monoclonal antibodies to specifically deliver cytotoxic drugs to tumor cells, characterized by precise targeting and specific killing of tumors, thereby limiting the exposure of cytotoxic drugs to normal cells or tissues. The main clinical toxicities of ADC drugs include gastrointestinal, hematological, hepatic, neurological, and ocular toxicities, which are usually dose-limiting[2]. Depending on … Read more