microfluidics

Lab Chip | 3D Printing + Standard Fluorescence Microscopy: Low-Cost Fabrication of Micron-Scale Biological Structures

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Lab Chip | 3D Printing + Standard Fluorescence Microscopy: Low-Cost Fabrication of Micron-Scale Biological Structures

Journal: Lab on a Chip (IF=5.4) Publication Date: July 14, 2025 Original Link: https://doi.org/10.1039/d5lc00181a Researchers from the University of Bern, Switzerland, proposed a microfabrication method that combines 3D printing technology with standard fluorescence microscopy, achieving maskless lithography through Digital Micromirror Device (DMD). This method enables micron-level precision micro-manufacturing without the need for a cleanroom. The … Read more

3D Printing Issue 5: Breakthrough in Embedded Microfluidic Chips via Two-Photon Lithography

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3D Printing Issue 5: Breakthrough in Embedded Microfluidic Chips via Two-Photon Lithography

“This article presents a novel process based on TPL, combined with the CWI development system, successfully fabricating embedded microfluidic chips with channel sizes reaching 30 μm and complex structures, enabling functions such as droplet generation and efficient cell sorting. This technology is expected to significantly enhance the resolution, compactness, and customization capabilities of microfluidic devices, … Read more

Multimodal Microfluidic 3D Printing Achieves Low-Temperature Polymerization of Hydrogels

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Multimodal Microfluidic 3D Printing Achieves Low-Temperature Polymerization of Hydrogels

Hydrogels, as a hydrophilic three-dimensional network polymer, have shown tremendous application potential in cutting-edge fields such as tissue engineering, drug delivery, and soft robotics in recent years. However, traditional hydrogels often suffer from poor mechanical properties and limited molding methods, making it difficult to meet the demands of complex application scenarios. Frontal polymerization (FP), an … Read more

AI-Mediated Encoding-Decoding for Multiplexed Microfluidic Digital Immunoassay Based on Computer Vision

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AI-Mediated Encoding-Decoding for Multiplexed Microfluidic Digital Immunoassay Based on Computer Vision

Hello everyone, today I would like to share a paper published in 2023 in Talanta, titled “Computer Vision-Based Artificial Intelligence-Mediated Encoding-Decoding for Multiplexed Microfluidic Digital Immunoassay.” This paper develops a multidimensional digital immunoassay through particle-based encoding and AI-based decoding, achieving high sensitivity and convenient multiplex detection. The encoded information in the characteristics of microspheres, including … Read more

Multimodal Microfluidic 3D Printing of Hydrogel for Low-Temperature Polymerization

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Multimodal Microfluidic 3D Printing of Hydrogel for Low-Temperature Polymerization

Hydrogels, as a hydrophilic three-dimensional network polymer, have shown great application potential in cutting-edge fields such as tissue engineering, drug delivery, and soft robotics in recent years. However, traditional hydrogels often suffer from poor mechanical properties and limited molding methods, making it difficult to meet the demands of complex application scenarios. Frontal polymerization (FP) is … Read more

Wide Dynamic Range Multiplex Digital CRISPR Chip for Absolute Quantification of Nucleic Acids

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Wide Dynamic Range Multiplex Digital CRISPR Chip for Absolute Quantification of Nucleic Acids

01Research Overview With the rapid development of molecular diagnostic technologies, digital CRISPR technology has become an important tool for nucleic acid detection due to its single-molecule counting and absolute quantification capabilities. However, traditional digital CRISPR platforms face significant challenges in several aspects. Firstly, most existing platforms adopt equal-volume microcavity designs, which typically cover a dynamic … Read more

When Stem Cells Meet 3D Printing! Biofabrication: Microfluidic Bioprinting Technology Successfully ‘Prints’ Functional Kidney Organoids Responsive to Drugs

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When Stem Cells Meet 3D Printing! Biofabrication: Microfluidic Bioprinting Technology Successfully 'Prints' Functional Kidney Organoids Responsive to Drugs

Globally, chronic kidney disease (CKD) is becoming an increasingly severe health threat—statistics show that it affects about 10% of the population and ranks among the top ten causes of death in low- and middle-income countries. When the condition progresses to end-stage renal disease (ESRD), patients often rely on dialysis or kidney transplantation to sustain life, … Read more

Principles of POCT Technology | Chemiluminescence, Biosensors, Microfluidics, Immunochromatography…

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Principles of POCT Technology | Chemiluminescence, Biosensors, Microfluidics, Immunochromatography...

01 Dry Chemical Analysis Technology Dry chemical technology is compared to traditional wet chemical technology, where the liquid present in the sample serves as the reaction medium. The components to be measured react directly with dry reagents fixed on a carrier, allowing for qualitative observation or instrument detection (semi-quantitative) for chemical analysis. Single-layer Test Paper … Read more

A Novel Label-Free Method for High-Throughput Single-Cell Analysis Integrating Computer Vision and Microfluidics

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A Novel Label-Free Method for High-Throughput Single-Cell Analysis Integrating Computer Vision and Microfluidics

Hello everyone, today I would like to share a paper published in 2023 in Microsystems & Nanoengineering, titled “Computer vision meets microfluidics: a label-free method for high-throughput cell analysis”. This study reviews the integration of microfluidic chips with computer vision, which has great potential in the analysis of single-cell imaging data. A key advantage of … Read more

ACS Nano: A Fully Integrated Wearable Biomimetic Microfluidic Wound Tracker for In Situ Dynamic Monitoring of Wound Exudate Oxygen

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ACS Nano: A Fully Integrated Wearable Biomimetic Microfluidic Wound Tracker for In Situ Dynamic Monitoring of Wound Exudate Oxygen

Wearable wound exudate sensors hold great promise for dynamic measurements of valuable biomarkers. However, existing sensors fail to achieve fully integrated, skin-adhered, and dynamic detection of raw wound exudate oxygen (O2), which is closely related to wound conditions and is crucial for wound healing. Here, we report a fully integrated wearable biomimetic microfluidic wound tracker … Read more