Breaking Through Device Bottlenecks: Avidity-Driven Targeted Fragment Drug Screening

Breaking Through Device Bottlenecks: Avidity-Driven Targeted Fragment Drug Screening

Recently, Professor Thomas Kodadek’s team at the University of Florida published a research paper titled “Exploiting Avidity Effects for the Discovery of Low-Affinity Protein-Binding Fragments” in the Journal of Medicinal Chemistry. This groundbreaking fragment drug screening technology innovatively utilizes avidity effects, successfully developing a new platform for efficient and low-cost fragment screening. Research Background Fragment-based … Read more

Biosensor Exploration: Enhancing L-Threonine Production in Escherichia coli

Biosensor Exploration: Enhancing L-Threonine Production in Escherichia coli

L-Threonine is an essential amino acid with high demand in the feed, food, and pharmaceutical industries. Although systematic metabolic engineering has enabled Escherichia coli to produce L-threonine at a concentration exceeding 120 g/L, achieving both high yield and productivity remains challenging due to the complexity of the metabolic network and the difficulty in identifying targets. … Read more

A Novel Label-Free Method for High-Throughput Single-Cell Analysis Integrating Computer Vision and Microfluidics

A Novel Label-Free Method for High-Throughput Single-Cell Analysis Integrating Computer Vision and Microfluidics

Hello everyone, today I would like to share a paper published in 2023 in Microsystems & Nanoengineering, titled “Computer vision meets microfluidics: a label-free method for high-throughput cell analysis”. This study reviews the integration of microfluidic chips with computer vision, which has great potential in the analysis of single-cell imaging data. A key advantage of … Read more

Progress in High-Throughput Screening Research Based on Small Molecule Sensors for Actinomycetes

Progress in High-Throughput Screening Research Based on Small Molecule Sensors for Actinomycetes

Actinomycetes can produce a wide variety of secondary metabolites, and microbial fermentation is an important means for obtaining these natural products. For a specific target product, the yield from wild strains is generally insufficient to meet industrial production requirements, necessitating long-term strain domestication to enhance yield. The combination of small molecule biosensors and droplet microfluidics … Read more