The World Under the Microscope—— Immunocytochemistry Definition: Immunocytochemistry (ICC) is a technique established on the basis of immunology, biochemistry, and microscopy technology. It detects the presence and distribution of certain polypeptides, proteins, and large molecular substances such as membrane surface antigens and receptors in cells according to the specific binding characteristics between antigens and antibodies. … Read more
Journal: Lab on a Chip (IF=5.4) Publication Date: July 14, 2025 Original Link: https://doi.org/10.1039/d5lc00181a Researchers from the University of Bern, Switzerland, proposed a microfabrication method that combines 3D printing technology with standard fluorescence microscopy, achieving maskless lithography through Digital Micromirror Device (DMD). This method enables micron-level precision micro-manufacturing without the need for a cleanroom. The … Read more
Subcellular organelles in cells often have intricate three-dimensional structures and biological functions. Observing the three-dimensional distribution and dynamics of organelles using fluorescence microscopy helps understand cellular functions and reveals interactions between organelles. However, fluorescence microscopy is limited by optical diffraction and the numerical aperture (NA) of the objective lens, resulting in blurred low-resolution images. Due … Read more