Introduction Antibody-drug conjugates(ADC) are formed by linking monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. ADC consists of three main components: the antibody responsible for selectively recognizing cancer cell surface antigens, the drug … Read more
The cancer-associated fibroblast (CAF) barrier in pancreatic ductal adenocarcinoma (PDAC) significantly restricts clinical prognosis. The main obstacles in PDAC treatment include limited immune cell and drug penetration, as well as an immunosuppressive microenvironment. Based on this, Yongjun Liu and Na Zhang from Shandong University reported a “shooting fish in a barrel” strategy by preparing a … Read more
Recently, Associate Professor Zhang Wenli’s team at China Pharmaceutical University published a review titled “The Janus of Protein Corona on Nanoparticles for Tumor Targeting, Immunotherapy and Diagnosis” in Journal of Controlled Release, Volume 345, 2022, and it was selected as the Inside Back Cover article of that issue.. Figure 1. The dual-edged effect of protein … Read more
Sonodynamic therapy (SDT) is a non-invasive treatment method based on reactive oxygen species (ROS) that interacts with ultrasound (US) activated sonosensitizers and surrounding oxygen and water molecules to produce highly cytotoxic ROS and induce apoptosis. Due to its ability to penetrate deep tissues while causing minimal damage to normal cells, it has significant potential in … Read more
iNature Immunotherapy shows great promise in cancer treatment. However, the highly immunosuppressive nature of solid tumors limits its effectiveness. On October 15, 2024, the research paper titled “Zinc-Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy” was published online in ACS Nano by Cheng Liang from Soochow University and Hou … Read more
iNature Activating the STING pathway in the cytosol of tumor-infiltrating antigen-presenting cells (APCs) can trigger an effective antitumor immune response for cancer treatment. However, most STING agonists are hydrophilic small molecules that face rapid clearance and poor cytosolic delivery issues after systemic administration. Although various nanoparticles have been developed to facilitate cytosolic delivery, they often … Read more
Autoimmune encephalitis (AE) refers to encephalitis mediated by autoimmune mechanisms. Those associated with tumors are termed paraneoplastic AE, while those without tumors are classified based on the presence of autoantibodies against neuronal cell surface or synaptic proteins. Currently, clinically detectable antibodies include N-methyl-D-aspartate receptor (NMDAR) antibodies, anti-gamma-aminobutyric acid-B receptor (GABABR) antibodies, anti-leucine-rich glioma inactivated 1 … Read more
Author: Cornflower This article is published with the author’s permission by Yiliao Tong. Please do not reproduce without authorization. Human epidermal growth factor receptor 2 (HER2) positive breast cancer is a highly aggressive molecular subtype with poor prognosis. The advent of anti-HER2 targeted therapies has significantly improved its prognosis. Currently, international standards generally consider that … Read more