Chemotherapy, as one of the main options for cancer treatment, has limited selectivity for cancer cells, a narrow therapeutic window, and potential high toxicity, which restricts its clinical application. Antibody-drug conjugates (ADCs), as emerging anticancer therapeutics, can deliver highly cytotoxic molecules directly to cancer cells to exert their lethal effects. ADCs are formed by the … Read more
Introduction Antibody-drug conjugates (ADCs) are composed of monoclonal antibodies targeting specific antigens linked to small molecule cytotoxic drugs via linkers. They combine the strong killing effect of traditional small molecule chemotherapy with the tumor-targeting ability of antibody drugs. ADCs consist of three main components: the antibody responsible for selectively recognizing cancer cell surface antigens, the … Read more
Authors: Lin Yuxuan, Xia Yong, Shen Feng Source: Chinese Journal of Hepatobiliary Surgery, 2023, 29(7) Abstract Intrahepatic cholangiocarcinoma (ICC) is a type of adenocarcinoma originating from the intrahepatic secondary bile ducts and their branches, characterized by high malignancy and poor prognosis. Radical surgical resection is currently the only potentially curative treatment for ICC, but only … Read more
Primary liver cancer is a common malignant tumor in China, including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and mixed hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA), with HCC accounting for 75% to 85% and ICC for 10% to 15%[1, 2]. Although the incidence of cholangiocarcinoma is low, its malignancy is very high, with most patients diagnosed at an advanced … Read more
Intrahepatic cholangiocarcinoma (ICC) is a lethal malignant tumor, with an incidence rate ranking second among primary liver cancers. In the past decade, the incidence of this disease has increased by 140%. ICC accounts for 20% of all liver malignancies, and 3% of all gastrointestinal malignancies. The disease typically develops against a background of chronic inflammation, … Read more
Click the blue text above“ioncology” to follow us, then click the “…” menu in the upper right corner and select “Set as Favorite”Neoadjuvant concurrent chemoradiotherapy remains the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). Recent studies have also shown survival advantages from neoadjuvant chemotherapy alone, but the improvement in pathological complete response … Read more
Click the blue text above“ioncologyGI” to follow us, then click the “…” menu in the upper right corner and select “Set as Favorite”Neoadjuvant concurrent chemoradiotherapy remains the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). Recent studies have also shown survival advantages from neoadjuvant chemotherapy alone, but the improvement in pathological complete response … Read more
Click below to follow and learn more about anti-cancer knowledge 👇 For patients with HER2 mutations in non-small cell lung cancer, past treatments have primarily involved chemotherapy, immunotherapy combined with chemotherapy, and anti-angiogenic therapy combined with chemotherapy. With the rise of antibody-drug conjugates (ADC), the treatment prospects for HER2 mutation patients are becoming increasingly clear. … Read more
Gastric cancer can be classified based on anatomical locations into: cardia cancer (gastric cardiacancer, GCC), fundic cancer, body cancer, antral cancer, and mixed type (two or more sites) cancer. The composition ratio of gastric cancer at different sites is undergoing significant changes, with a trend towards proximal development. In recent decades, the incidence of cardia … Read more
Organized by: Oncology Information Source: Oncology Information Recently, a prospective study published by Professor Zhang Mingzhi, Professor Chen Qingjiang, and Professor Zhang Xudong from Zhengzhou University First Affiliated Hospital in Frontiers in Oncology (impact factor 6.244) evaluated the efficacy and safety of decitabine (DAC) combined with cisplatin, cytarabine, and dexamethasone (DHAP) modified regimen in patients … Read more