Today we share a study published in June 2025 in J Am Soc Nephrol: Molecular Mechanisms of Sepsis-Associated Acute Kidney Injury. This review aims to refine the timeline of sepsis-associated acute kidney injury by analyzing the key molecular events driving disease progression, thereby providing information for rational treatment strategies. 1.Research Background and Core Issues 1.1The … Read more
Abstract Abstract Introduction Sepsis-induced myocardial dysfunction (SIMD) is a condition manifested by an intrinsic myocardial systolic and diastolic dysfunction during sepsis, which is associated with worse clinical outcomes and a higher mortality. Materials and methods Several pathophysiological mechanisms including mitochondrial dysfunction, abnormal body immune reaction, metabolic reprogramming, excessive production of reactive oxygen species (ROS), and … Read more
Click the blue text below the title to follow us This article was published in: Chinese Physician Magazine, 2022, 24(4): 496-499, 504. Cite this article: Pan Xingbang, Zhong Jie, Li Zhao, et al. Meta-analysis of the correlation between sepsis-induced myocardial dysfunction and hypertension [J]. Chinese Physician Magazine, 2022, 24(4): 496-499, 504. Authors Pan Xingbang (Department … Read more
Guo Rinnan, Tang Wen, Liu Yan Intensive Care Unit, Xinjiang Uygur Autonomous Region People’s Hospital, Urumqi 830001 International Journal of Anesthesiology and Resuscitation, 2024, 45(12): 1263-1269. DOI: 10.3760/cma.j.cn321761-20240625‑01168 ORIGINAL ARTICLES Currently, there are few studies on myocardial injury associated with sepsis after surgery (SIMD) in surgical patients with sepsis. This study aims to evaluate and … Read more
Follow us for more exciting content SIC Sepsis-Induced Cardiomyopathy (SIC) is an acute heart dysfunction that occurs in sepsis patients and is not related to ischemic injury, but lacks a unified diagnostic standard. Some biological markers can reflect the degree of heart damage and have certain auxiliary value for the early diagnosis of sepsis-induced cardiomyopathy. … Read more
Translation:Li Yanping Editor:Wei Yaping ②MSCs and Myocardial Injury in Sepsis. Septic Induced Myocardial Dysfunction (SIMD) is one of the most common complications of sepsis. The pathogenic factors of SIMD include the release of myocardial suppressive factors, upregulation of NO, impaired myocardial calcium homeostasis, and mitochondrial dysfunction. SIMD primarily manifests as myocardial ischemia and hypoxia, impaired … Read more
On August 11, researchers from the University of California, San Francisco, published a paper in the Annals of the American Thoracic Society titled “Host-Microbe Multiomic Profiling Predicts Mortality in Sepsis“, which establishes a mortality prediction model for sepsis through the integration of host-microbe multiomics analysis, providing a new perspective for understanding the complex pathological mechanisms … Read more
Authors: Wang Yixin, Sun Yunhui Affiliation: The First Affiliated Hospital of Jiamusi University 1. Procalcitonin Procalcitonin (PCT) is a non-hormonal precursor peptide glycoprotein that is released into the patient’s circulatory system as a soluble protein under conditions of severe systemic infection, particularly bacterial infections. Under normal physiological conditions, PCT, transcribed from the CALC-1 gene, is … Read more
Sepsis-Related Acute Kidney Injury Based on the Gut-Kidney Axis Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection[1,2]. The most common manifestation is multiple organ dysfunction, particularly renal dysfunction, known as sepsis-associated acute kidney injury (SA-AKI)[3]. SA-AKI is common in patients with severe sepsis, with an incidence of … Read more
Click on the blue text above to follow us Click on the “Miller Voice” → Click the upper right corner“…” → Select “Set as Starred “★ “ to add Miller Voice as a starred item, making it easier for you to find us later Translation by Yu Liqi, Department of Anesthesiology, Shanghai Public Health Clinical … Read more