Breaking Through the Challenges of Spatial Multi-Omics Integration! The MultiGATE Tool Emerges to Precisely Decode Tissue Microenvironments and Regulatory Networks

Breaking Through the Challenges of Spatial Multi-Omics Integration! The MultiGATE Tool Emerges to Precisely Decode Tissue Microenvironments and Regulatory Networks

In today’s rapidly developing field of spatial biology, spatial multi-omics technology can simultaneously capture multi-dimensional molecular information such as transcriptomes, epigenomes, and proteins from the same tissue slice, providing unprecedented opportunities for analyzing tissue heterogeneity and molecular regulatory mechanisms. However, efficiently integrating these multimodal data while mining spatial information and cross-modal regulatory relationships has been … Read more

Wang Chenxuan’s Team at the Institute of Basic Medical Sciences Reveals the Regulatory Mechanism of Non-Core Regions on the Conformational Diversity of Amyloid Aggregates

Wang Chenxuan's Team at the Institute of Basic Medical Sciences Reveals the Regulatory Mechanism of Non-Core Regions on the Conformational Diversity of Amyloid Aggregates

On September 4, 2025, the team led by Wang Chenxuan at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, published a paper titled “Beyond the Amyloid Core: Modulation of Aggregate Conformational Diversity by Mutations in the Noncore Regions” in the Journal of the American Chemical Society. This study, utilizing single-molecule techniques, reveals … Read more