1. Research Background Ribonucleic acid (RNA) plays a complex and central role in cellular regulation, catalysis, and signaling. Visualizing RNA during isolation and analysis, as well as in its natural cellular environment, is an important tool for analyzing its function. The ability to image populations of RNA can monitor cellular transcription, track the mobility and … Read more
1. Introduction Since Sir George Gabriel Stokes proposed the concept of fluorescence in 1845 and subsequent reports of fluorescence observed in natural compounds, the modern theoretical understanding of fluorescence has begun to form and continues to develop to this day. The characteristic features of fluorescence make it a potential tool for the visual detection of … Read more
Ribonucleic acid (RNA) plays a complex and central role in cellular regulation, catalysis, and signal transduction. Visualizing RNA in isolation and in the natural cellular environment is an important means of elucidating its functions. The ability to image populations of RNA enables monitoring of cellular transcriptional activity, tracking the migration and dynamics of various transcripts, … Read more
Hello everyone, today I would like to share an article published in J. Am. Chem. Soc. titled “Site-Specific Chemoselective Cyclization and Fluorogenic Modification of Protein Cysteine Residues: From Side-Chain to Backbone.” The corresponding author is Professor Sun Xiaolong from Xi’an Jiaotong University, who mainly researches fluorescent probes. In this article, the authors focus on the … Read more
Recently, the research team of Liu Qian and Zhang Yunxiang from the Department of Chemistry at Fudan University published a study titled “Enhanced Single-Molecule Imaging via Intersystem Crossing Suppression” in the Journal of the American Chemical Society. This research addresses the long-standing issues of “photobleaching” and “photoblinking” that have troubled researchers in single-molecule imaging, proposing … Read more