backbone cyclization

The Comeback of Inert Esters: Samarium(II) Iodide Mediated Radical 1,4-Ester Migration

by
The Comeback of Inert Esters: Samarium(II) Iodide Mediated Radical 1,4-Ester Migration

Image source: J. Am. Chem. Soc.Introduction: Samarium(II) iodide (SmI₂,Kagan reagent) mediated reduction cyclization reactions of carbonyl compounds provide an important platform for stereocontrolled construction of complex molecular structures. In addition to traditional ketone and aldehyde substrates, recent advances in radical chemistry have enabled lactones and lactams to undergo cyclization via SmI₂. However, acyclic ester compounds … Read more

Site-Specific Chemoselective Cyclization and Fluorogenic Modification of Protein Cysteine Residues: From Side-Chain to Backbone

by
Site-Specific Chemoselective Cyclization and Fluorogenic Modification of Protein Cysteine Residues: From Side-Chain to Backbone

Hello everyone, today I would like to share an article published in J. Am. Chem. Soc. titled “Site-Specific Chemoselective Cyclization and Fluorogenic Modification of Protein Cysteine Residues: From Side-Chain to Backbone.” The corresponding author is Professor Sun Xiaolong from Xi’an Jiaotong University, who mainly researches fluorescent probes. In this article, the authors focus on the … Read more