1. Research Background Ribonucleic acid (RNA) plays a complex and central role in cellular regulation, catalysis, and signaling. Visualizing RNA during isolation and analysis, as well as in its natural cellular environment, is an important tool for analyzing its function. The ability to image populations of RNA can monitor cellular transcription, track the mobility and … Read more
The nickel-catalyzed asymmetric reductive cross-coupling reaction can rapidly and modularly obtain enantiomer-rich building blocks from simple electrophilic precursors. The reductive coupling reaction can differentiate two different series of enantiomer-enriched products through a common organometallic intermediate, and this reaction has a particularly wide range of applications, but is underdeveloped. Here, the teams of Sarah E. Reisman … Read more
Hello everyone, this week I would like to share an article published in JACS titled Localized 2′-OH Acylation at Poly(A) Extends RNA Translation. The corresponding author is Professor Eric T. Kool from Stanford University, whose research group focuses on nucleic acid chemical modifications and RNA therapeutics. In the field of mRNA therapeutics, the integrity of … Read more