To address the critical challenge of “how to provide functional vascular networks for new tissues,” a joint research team from Linköping University and Sahlgrenska University Hospital in Sweden has developed a biphasic particle bioink based on gelatin and hyaluronic acid, named μInk. This material can construct dermal tissue substitutes with ultra-high cell density through 3D … Read more
Research Background In patients with ST-segment elevation myocardial infarction (STEMI), approximately 50% have multivessel disease (MVD), which is associated with a poor prognosis, especially when there are three-vessel lesions or chronic total occlusions. Although emergency PCI is the standard treatment for STEMI, there is still controversy regarding the management strategy for nonculprit lesions (complete revascularization … Read more
Research Background With the increasing number of elderly patients receiving primary percutaneous coronary intervention (PPCI), the management strategies for non-culprit lesions have become controversial. Although multiple studies support that complete revascularization (treating all significant stenosed vessels) can improve prognosis, the benefits for elderly patients (≥75 years) remain unclear due to their comorbidities and shorter life … Read more
Research Background Patients with ST-segment elevation myocardial infarction (STEMI) combined with multivessel disease (MVD) account for approximately 45% of all STEMI patients, and they have a poorer clinical prognosis. Previous studies (such as PRAMI, CvLPRIT) have shown that complete revascularization (treating all significantly narrowed vessels) can reduce major adverse cardiovascular events (MACE) compared to treating … Read more
Research Background and Objectives In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD), the strategy of complete revascularization (CRV) can reduce ischemic events, but its impact on bleeding risk remains unclear. Core Questions: – Does staged complete revascularization (FFR-guided) during hospitalization increase the risk of severe bleeding? – What is the impact … Read more