Multivessel Disease

MULTISTARS AMI Trial Shows Immediate vs. Staged Revascularization in STEMI Patients

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MULTISTARS AMI Trial Shows Immediate vs. Staged Revascularization in STEMI Patients

In patients with ST-segment elevation myocardial infarction (STEMI), approximately 50% have multivessel coronary artery disease, which is associated with an increased risk of recurrent myocardial infarction and death. The COMPLETE trial indicated that complete revascularization in patients with STEMI and multivessel coronary artery disease is superior to percutaneous coronary intervention (PCI) that only opens the … Read more

DANAMI 3-PRIMULTI Substudy – Complete Revascularization Guided by FFR Improves Prognosis in STEMI Patients with Severe Nonculprit Lesions

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DANAMI 3-PRIMULTI Substudy - Complete Revascularization Guided by FFR Improves Prognosis in STEMI Patients with Severe Nonculprit Lesions

Research Background In patients with ST-segment elevation myocardial infarction (STEMI), approximately 50% have multivessel disease (MVD), which is associated with a poor prognosis, especially when there are three-vessel lesions or chronic total occlusions. Although emergency PCI is the standard treatment for STEMI, there is still controversy regarding the management strategy for nonculprit lesions (complete revascularization … Read more

DANAMI-3-PRIMULTI Substudy—Cardiac Magnetic Resonance Confirms the Impact on Cardiac Structure and Function

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DANAMI-3-PRIMULTI Substudy—Cardiac Magnetic Resonance Confirms the Impact on Cardiac Structure and Function

Research Background Patients with ST-segment elevation myocardial infarction (STEMI) combined with multivessel disease (MVD) account for approximately 45% of all STEMI patients, and they have a poorer clinical prognosis. Previous studies (such as PRAMI, CvLPRIT) have shown that complete revascularization (treating all significantly narrowed vessels) can reduce major adverse cardiovascular events (MACE) compared to treating … Read more

Analysis of Bleeding Events in the DANAMI-3-PRIMULTI Substudy

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Analysis of Bleeding Events in the DANAMI-3-PRIMULTI Substudy

Research Background and Objectives In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD), the strategy of complete revascularization (CRV) can reduce ischemic events, but its impact on bleeding risk remains unclear. Core Questions: – Does staged complete revascularization (FFR-guided) during hospitalization increase the risk of severe bleeding? – What is the impact … Read more