Prognosis

Children’s T-ALL Fusion Gene TCF7::SPI1 Positive with NRAS Mutation: Poor Prognosis

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Children's T-ALL Fusion Gene TCF7::SPI1 Positive with NRAS Mutation: Poor Prognosis

Literature 1Literature 2 Children’s T-cell acute lymphoblastic leukemia (T-ALL) is classified as a medium-risk group within ALL. However, T-ALL can be further categorized: Low risk, medium risk, high risk. The five-year survival rate for T-cell acute lymphoblastic leukemia is overall lower than that of B-cell acute lymphoblastic leukemia. In T-ALL, another common classification method is: … Read more

Overview of Myelofibrosis Treatment and Research

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Overview of Myelofibrosis Treatment and Research

Compiled by: Moonlit LotusSource: Oncology Information Currently, JAK inhibitors (JAKi) are the most effective treatment options for myelofibrosis (MF), and research targeting other molecular pathways is actively ongoing. This article briefly introduces the diagnosis and outcomes of MF, focusing on existing treatments and ongoing research. It is evident that there is significant potential for the … Read more

A Novel Stemness-Related lncRNA Signature Predicts Prognosis, Immune Infiltration, and Drug Sensitivity in Clear Cell Renal Cell Carcinoma

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A Novel Stemness-Related lncRNA Signature Predicts Prognosis, Immune Infiltration, and Drug Sensitivity in Clear Cell Renal Cell Carcinoma

Tumor stemness refers to a subpopulation of tumor cells that possess stem cell-like characteristics, including self-renewal, differentiation into various cell types, and the ability to survive in harsh environments. This characteristic makes tumor cells more prone to recurrence and metastasis after treatment and leads to resistance to conventional therapeutic methods. Therefore, identifying and targeting stemness-related … Read more

DANAMI 3-PRIMULTI Substudy – Complete Revascularization Guided by FFR Improves Prognosis in STEMI Patients with Severe Nonculprit Lesions

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DANAMI 3-PRIMULTI Substudy - Complete Revascularization Guided by FFR Improves Prognosis in STEMI Patients with Severe Nonculprit Lesions

Research Background In patients with ST-segment elevation myocardial infarction (STEMI), approximately 50% have multivessel disease (MVD), which is associated with a poor prognosis, especially when there are three-vessel lesions or chronic total occlusions. Although emergency PCI is the standard treatment for STEMI, there is still controversy regarding the management strategy for nonculprit lesions (complete revascularization … Read more

Subgroup Analysis of DANAMI-3-PRIMULTI: The Impact of Age on Prognosis After Complete Revascularization

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Subgroup Analysis of DANAMI-3-PRIMULTI: The Impact of Age on Prognosis After Complete Revascularization

Research Background With the increasing number of elderly patients receiving primary percutaneous coronary intervention (PPCI), the management strategies for non-culprit lesions have become controversial. Although multiple studies support that complete revascularization (treating all significant stenosed vessels) can improve prognosis, the benefits for elderly patients (≥75 years) remain unclear due to their comorbidities and shorter life … Read more

Establishment and Application of Preoperative Scoring System for Resectable Pancreatic Cancer

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Establishment and Application of Preoperative Scoring System for Resectable Pancreatic Cancer

Pancreatic cancer is a highly malignant and lethal tumor, with a high incidence and extremely poor prognosis. According to the 2021 cancer data from the United States, the incidence of pancreatic cancer continues to rise, ranking 10th among new cases in men and 9th in women, with a mortality rate that ranks 4th among all … Read more