Selection of Target Antigens in ADC Design

Source: Xiaoyao Shuo Yao Introduction Antibody-drug conjugates (ADC) are a powerful cancer treatment method that combines monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs linked by a linker. ADCs utilize the specificity of antibodies for their target antigens, combined with the potency of cytotoxic drugs, to selectively kill tumor cells expressing the target … Read more

Review of ADC Drugs: Current Status and Future Directions

Antibody-Drug Conjugates (ADCs) are one of the fastest-developing treatments in the field of oncology, with 15 ADCs already approved and over 210 currently undergoing clinical trials. In recent years, the development of ADC drugs has entered a flourishing phase, especially demonstrating significant efficacy and good safety profiles against targets such as HER2, EGFR, Trop2, CLDN18.2, … Read more

Fundamentals of Clinical Pharmacology of ADCs

Antibody-drug conjugates (ADC) are formed by linking monoclonal antibodies that target specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. Since the first ADC (Gemtuzumab-ozogamicin, trade name: Mylotarg) was approved for the treatment of CD33-positive acute myeloid … Read more

Research on ADC Combination Therapy

Introduction Antibody-drug conjugates(ADC) are formed by linking monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. ADC consists of three main components: the antibody responsible for selectively recognizing cancer cell surface antigens, the drug … Read more

Comprehensive Overview of ADC Drug Development

What Is ADC? Antibody-drug conjugates (ADC) are a new type of targeted therapeutic drug, composed of monoclonal antibodies that specifically target antigens linked to small molecule cytotoxic drugs via linkers. They combine the powerful killing effect of traditional small molecule chemotherapy with the tumor-targeting capability of antibody drugs. This structure allowsADC to deliver drugs directly … Read more

Analysis of Voltage Drop, Grounding, and Short Circuit Issues in Fire Alarm Bus Lines

In the design, application, and selection process of fire automatic alarm systems, most people pay attention to the appearance, sensitivity, stability, and intelligence level of fire detectors, as well as the performance, interface, and functionality of the main unit… However, during actual engineering construction, there are some seemingly simple yet crucial aspects that require our … Read more

Understanding the Working Principle of CAN Bus

Click the above “Easy Learning Electronics” to follow and easily learn electronic knowledge. Easy Learning Electronics Subscription Daily updates on technical articles in the electronics industry and the latest news on microcontrollers, making it easy to learn anytime, anywhere. In a CAN bus, the priority of messages sent by all transceivers ranges from the least … Read more

Handling Fire Alarm System Circuit Short Circuits and Device Failures

Fire Alarm System Circuit Bus Short Circuit Handling Methods When a certain circuit bus of the fire alarm system experiences a short circuit and the current between wires is too high, the controller emits sound and light alarms, while displaying a short circuit on the LCD screen in Chinese (see the image below). The printer … Read more

Basics and Applications of Microcontrollers | 06 Microcontroller Parallel Memory Expansion

Click the blue words to follow us 1. Microcontroller Parallel External Expansion System 1. Microcontroller Parallel External Expansion System External expansion is an important aspect of building a microcontroller system, which can be categorized into two types: Memory expansion and I/O expansion; There are two methods for external expansion: parallel expansion and serial expansion. 2. … Read more

Analysis of Fire Alarm System Issues: Bus Line Voltage Drop, Grounding, and Short Circuit Problems

In the design, application, and selection process of fire automatic alarm systems, we often pay attention to the appearance, sensitivity, stability, and intelligence level of fire detectors, as well as the performance, interface, and functions of the control panel. However, during actual engineering construction, there are some seemingly simple issues that deserve our close attention. … Read more