Year: 2025

Cutting-Edge Sequencing Technologies: A Detailed Introduction to Single-Molecule Optical Mapping

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Cutting-Edge Sequencing Technologies: A Detailed Introduction to Single-Molecule Optical Mapping

The eukaryotic genome exhibits various repetitive sequences (such as centromeres, telomeres, etc.) and long gaps, which increasingly highlight the shortcomings of existing sequencing technologies. Although second-generation sequencing technologies can cheaply generate a large amount of sequencing data, their read length limitations prevent a simple and intuitive view of structural changes across the entire genome; PacBio … Read more

P.S. Lee Team at NTU: Low-Temperature Atomic Layer Deposition Enhances Performance of Flexible Thin-Film Transistors

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P.S. Lee Team at NTU: Low-Temperature Atomic Layer Deposition Enhances Performance of Flexible Thin-Film Transistors

With the development and application of microelectronics technology, flexible thin-film transistors with characteristics such as bendability, deformability, and portability have attracted extensive research in fields such as wearable health management devices and flexible displays. Flexible thin-film transistors made of metal oxides, although they have better performance and stability compared to transistors made from carbon nanotubes … Read more

Major Challenges and Industrial Outlook of Sodium Battery Membranes

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Major Challenges and Industrial Outlook of Sodium Battery Membranes

First Author: Xue Zhixin Corresponding Author: Xu Guiyin Affiliation: Donghua University Summary of Results Sodium-ion batteries (SIBs) are receiving widespread attention due to their low cost, low-temperature performance, and fast charging capabilities. The membrane is one of the essential key components of the battery, affecting the battery’s interface structure, internal resistance, capacity, cycle life, and … Read more

Zinc-Nickel Bimetallic Hydroxide Nanosheets Enhance Tumor Immunotherapy

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Zinc-Nickel Bimetallic Hydroxide Nanosheets Enhance Tumor Immunotherapy

iNature Immunotherapy shows great promise in cancer treatment. However, the highly immunosuppressive nature of solid tumors limits its effectiveness. On October 15, 2024, the research paper titled “Zinc-Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy” was published online in ACS Nano by Cheng Liang from Soochow University and Hou … Read more

NIR-II Ratiometric Optical Theranostic Capsule for Intestinal Inflammation

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NIR-II Ratiometric Optical Theranostic Capsule for Intestinal Inflammation

iNature In clinical practice, capsules are widely used for oral administration of various drugs, but real-time tracking of drug release behavior and adjusting dosage based on therapeutic effects remains challenging. On December 11, 2024, Song Jibin from Beijing University of Chemical Technology and Mu Jing from Peking University co-authored a research paper titled “NIR-II Ratiometric … Read more

Dual Frequency-Regulated Magnetic Vortex Nanorobots for Thrombolysis

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Dual Frequency-Regulated Magnetic Vortex Nanorobots for Thrombolysis

iNature Due to the non-invasive remote driving and drug loading capabilities of magnetic nanorobots, there are broad application prospects in thrombolytic therapy. Although nanorobots smaller than 100 nanometers are suitable for microvascular systems, their propulsion performance is severely affected due to limited response to magnetic fields. On October 18, 2024, Cheng Yu and He Bin … Read more

Consensus on RNA Genetic Modification for siRNA Delivery Using Negative-Charged Nano-Ultrasound Contrast Agents

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Consensus on RNA Genetic Modification for siRNA Delivery Using Negative-Charged Nano-Ultrasound Contrast Agents

Shandong Provincial Medical Association of Ultrasound Submission Date: 2022-11-01 Corresponding Author: Li Jie, Email: [email protected]. Abstract:Nano-ultrasound contrast agents possess unique features such as liquid-gas phase transition and acoustic cavitation effects, making them important potential carriers for siRNA delivery. Currently, siRNA loading is mainly achieved through electrostatic attraction, requiring the construction of positively charged contrast agents … Read more

Nano Energy Develops Self-Powered Friction Sensor for Wearable Monitoring

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Nano Energy Develops Self-Powered Friction Sensor for Wearable Monitoring

This article is reproduced from the WeChat public account “Tianjin Medical University” Fang Zhongze Professor at Tianjin Medical University, PhD supervisor, Vice Dean of the School of Public Health, Executive Deputy Director of the National Preventive Medicine Experimental Teaching Center, Director of the Department of Health Toxicology and Health Inspection and Quarantine, and Deputy Director … Read more

Potent Covalent Organic Framework Nanophotosensitizers for Photodynamic Immunotherapy

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Potent Covalent Organic Framework Nanophotosensitizers for Photodynamic Immunotherapy

iNature The photodynamic therapy (PDT) using oxygen-dependent type II photosensitizers is often limited by the hypoxic microenvironment of solid tumors. Type I photosensitizers generate oxygen-independent reactive oxygen species (ROS) under light irradiation, but they suffer from aggregation-caused quenching (ACQ) and low ROS generation efficiency. On December 19, 2024, the team led by Ge Zhishen from … Read more

Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Activate Antitumor Immune Response

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Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Activate Antitumor Immune Response

iNature Activating the STING pathway in the cytosol of tumor-infiltrating antigen-presenting cells (APCs) can trigger an effective antitumor immune response for cancer treatment. However, most STING agonists are hydrophilic small molecules that face rapid clearance and poor cytosolic delivery issues after systemic administration. Although various nanoparticles have been developed to facilitate cytosolic delivery, they often … Read more