Gene Delivery

BindCraft: A One-Shot Protein Design Tool for Functional Protein Binders (Nature 2025)

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BindCraft: A One-Shot Protein Design Tool for Functional Protein Binders (Nature 2025)

BindCraft is a new computational tool designed for the one-shot method of creating functional protein binders. https://www.nature.com/articles/s41586-025-09429-6 Here are some key points from the paper: [Apologies for the long delay in updates] What is BindCraft? BindCraft is an open-source, automated one-stop protein binder design process aimed at simplifying the de novo design of protein binders. … Read more

Consensus on RNA Genetic Modification for siRNA Delivery Using Negative-Charged Nano-Ultrasound Contrast Agents

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Consensus on RNA Genetic Modification for siRNA Delivery Using Negative-Charged Nano-Ultrasound Contrast Agents

Shandong Provincial Medical Association of Ultrasound Submission Date: 2022-11-01 Corresponding Author: Li Jie, Email: [email protected]. Abstract:Nano-ultrasound contrast agents possess unique features such as liquid-gas phase transition and acoustic cavitation effects, making them important potential carriers for siRNA delivery. Currently, siRNA loading is mainly achieved through electrostatic attraction, requiring the construction of positively charged contrast agents … Read more