molecular self-assembly

Self-Assembly of Artificial Topological Nanostructures for Enhanced Bioorthogonal Activation and Drug Penetration in Cancer Immunotherapy

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Self-Assembly of Artificial Topological Nanostructures for Enhanced Bioorthogonal Activation and Drug Penetration in Cancer Immunotherapy

1. Research Background Despite significant efforts by scientists in developing cancer vaccines based on new antigens or mRNA, most research still focuses on the preventive stage. Eliciting substantial anti-tumor immune responses in patients remains a major challenge, primarily due to the weak immunogenicity of cancer vaccines, the immunosuppressive tumor microenvironment, and the low correlation between … Read more

Template and Solid-State-Assisted Assembly of an M9L6 Expanded Coordination Cage for Medium-Sized Molecule Encapsulation

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Template and Solid-State-Assisted Assembly of an M9L6 Expanded Coordination Cage for Medium-Sized Molecule Encapsulation

In the mid-1990s, through molecular self-assembly techniques, larger three-dimensional closed cavities were effectively constructed. The M6L4 cage is one of the most efficient self-assembling hosts, formed by the self-assembly of six Pd(II) or Pt(II) 90-degree blocks and four triazine-core triangular ligands, featuring an effective hydrophobic cavity of approximately 450 Å3 capable of encapsulating one or … Read more

How 3D Printing Creates Self-assembling Superconductors

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How 3D Printing Creates Self-assembling Superconductors

Cornell University researchers have unveiled a novel method for manufacturing superconductors that relies on specialized 3D printing inks and self-assembly techniques to create specific nanostructures. This strategy enables engineers to produce superconductors with specific characteristics and properties using less investment and fewer specialized devices. It has the potential to revolutionize fields such as computing and … Read more

Self-Assembly of Alkynyl Platinum(II) Complexes and Their Application in Sialic Acid Detection and Differentiation of Cancer Cells from Normal Cells

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Self-Assembly of Alkynyl Platinum(II) Complexes and Their Application in Sialic Acid Detection and Differentiation of Cancer Cells from Normal Cells

In the field of life sciences, the sugar chains on the surface of cells act as complex “molecular codes” that carry critical biological information. Among them, sialic acid, a sugar molecule with a nine-carbon backbone, is typically located at the terminal of cell surface sugar chains and plays an important role in various biological processes … Read more

A New Strategy for Nanosuspension Stabilizer Screening Based on Computer-Aided Drug Design and Molecular Self-Assembly

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A New Strategy for Nanosuspension Stabilizer Screening Based on Computer-Aided Drug Design and Molecular Self-Assembly

Nanosuspensions (NS) are considered dispersions of drug particles with a particle size of less than 1μm (most commonly 200-500nm) that are stabilized by adding suitable polymers and/or surfactants. By dispersing drugs into nanoscale particles, nanosuspensions significantly increase the specific surface area of the drug, thereby promoting drug dissolution and significantly improving its release performance and … Read more