sialic acid

Literature Sharing | J. Am. Chem. Soc. | Alkynyl Platinum Complex Self-Assembly for Sialic Acid Detection and Differentiation of Cancer Cells from Normal Cells

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Literature Sharing | J. Am. Chem. Soc. | Alkynyl Platinum Complex Self-Assembly for Sialic Acid Detection and Differentiation of Cancer Cells from Normal Cells

The team led by Ren Yonghua at the University of Hong Kong designed and synthesized a series of platinum(II) complexes containing histidine moieties or positively charged groups to explore the specific binding and sensing capabilities of platinum(II) complexes with analytes. These complexes are used to visualize changes in sialic acid within cells, distinguishing between normal … Read more

Self-Assembly of Alkynyl Platinum(II) Complexes and Their Application in Sialic Acid Detection and Differentiation of Cancer Cells from Normal Cells

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Self-Assembly of Alkynyl Platinum(II) Complexes and Their Application in Sialic Acid Detection and Differentiation of Cancer Cells from Normal Cells

In the field of life sciences, the sugar chains on the surface of cells act as complex “molecular codes” that carry critical biological information. Among them, sialic acid, a sugar molecule with a nine-carbon backbone, is typically located at the terminal of cell surface sugar chains and plays an important role in various biological processes … Read more

Literature Sharing | J. Am. Chem. Soc. | Functionalized Boron-Containing Pentacyclic Sialic Acid Probes for High-Fidelity Fluorescence Imaging of Cancer Tissues

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Literature Sharing | J. Am. Chem. Soc. | Functionalized Boron-Containing Pentacyclic Sialic Acid Probes for High-Fidelity Fluorescence Imaging of Cancer Tissues

The team led by Professor Young-Tae Chang at Pohang University of Science and Technology in South Korea has developed a fluorescence probe (SLY) based on boron-doped heteroaromatic compounds for the specific recognition of sialylated Lewis antigens (sLex and sLea) that are overexpressed on the cell surface, achieving high-fidelity fluorescence imaging of cancer regions at both … Read more