Inflammation

Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes

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Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes

On August 11, a communication from Mark Toshner at Papworth Royal Hospital was published in the Annals of the American Thoracic Society titled “Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes.” This multicenter study systematically reveals for the first time the complex association between C-reactive protein (CRP) and body mass index … Read more

Bone Grafting Treatment for Periodontitis: 3D Printed Bone Grafting Technology

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Bone Grafting Treatment for Periodontitis: 3D Printed Bone Grafting Technology

Periodontitis, also known as gum disease, is one of the most common oral diseases, affecting 4 out of 10 adults aged 30 and older, and 60% of seniors aged 65 and above. According to a 2018 study by JADA, the age group over 65 is one of the most prevalent among patients with severe periodontitis … Read more

C-Reactive Protein vs Procalcitonin: Which Has the Advantage?

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C-Reactive Protein vs Procalcitonin: Which Has the Advantage?

Authors: Wang Yixin, Sun Yunhui Affiliation: The First Affiliated Hospital of Jiamusi University 1. Procalcitonin Procalcitonin (PCT) is a non-hormonal precursor peptide glycoprotein that is released into the patient’s circulatory system as a soluble protein under conditions of severe systemic infection, particularly bacterial infections. Under normal physiological conditions, PCT, transcribed from the CALC-1 gene, is … Read more

Sepsis-Related Acute Kidney Injury Based on the Gut-Kidney Axis

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Sepsis-Related Acute Kidney Injury Based on the Gut-Kidney Axis

Sepsis-Related Acute Kidney Injury Based on the Gut-Kidney Axis Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection[1,2]. The most common manifestation is multiple organ dysfunction, particularly renal dysfunction, known as sepsis-associated acute kidney injury (SA-AKI)[3]. SA-AKI is common in patients with severe sepsis, with an incidence of … Read more

Understanding C-Reactive Protein

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Understanding C-Reactive Protein

What does C-Reactive Protein look like? C-Reactive Protein (CRP) is a symmetrical, cyclic pentamer, with a half-life of only 5-7 hours in the metabolic cycle. ▼ The synthesis of C-Reactive Protein in the body C-Reactive Protein is synthesized in the liver and epithelial cells stimulated by inflammatory lymphokines (interleukin-6, interleukin-1, tumor necrosis factor TNF). What … Read more

A Review of Transcranial Photobiomodulation for Major Depressive Disorder: Targeting Brain Metabolism, Inflammation, Oxidative Stress, and Neurogenesis (Part 4 of 4)

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A Review of Transcranial Photobiomodulation for Major Depressive Disorder: Targeting Brain Metabolism, Inflammation, Oxidative Stress, and Neurogenesis (Part 4 of 4)

This article is a translation and reprint from Neurophotonics. July 2016; 3(3): 031404. Published online on March 4, 2016. doi: 10.1117/1.NPh.3.3.031404 PMCID: PMC4777909 PMID: 26989758 A Review of Transcranial Photobiomodulation for Major Depressive Disorder: Targeting Brain Metabolism, Inflammation, Oxidative Stress, and Neurogenesis Paolo Cassano,a,b,* Samuel R. Petrie,a Michael R. Hamblin,c,d,e Theodore A. Henderson,f,g and Dan … Read more

Mechanisms and Prevention of Acute Pancreatitis Complicating Liver Failure

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Mechanisms and Prevention of Acute Pancreatitis Complicating Liver Failure

Liver failure is a severe destruction of hepatocytes triggered by various pathological factors, leading to significant liver dysfunction. In clinical practice, it is often characterized by ascites, jaundice, hepatorenal syndrome, and infections, commonly associated with systemic inflammatory response syndrome. Its onset is rapid, the progression is swift, and it has many complications, making it extremely … Read more

Detailed Explanation of C-Reactive Protein

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Detailed Explanation of C-Reactive Protein

CRP is an acute phase protein synthesized by liver cells in response to inflammatory stimuli such as microbial invasion or tissue damage. The acute phase response includes changes in the concentration of certain serum proteins during infection, inflammation, and trauma. These proteins, in addition to CRP, include serum amyloid A, fibrinogen, haptoglobin, α1-acid glycoprotein, ceruloplasmin, … Read more

How Inflammation Promotes Atherosclerosis: The Key Steps

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How Inflammation Promotes Atherosclerosis: The Key Steps

▎Content Team of WuXi AppTec Edited Lipid accumulation and hypertension are considered major risk factors for atherosclerotic cardiovascular disease (ASCVD). Cholesterol-lowering and antihypertensive medications are expected to effectively prevent and eliminate ASCVD. However, intervention strategies based on hypercholesterolemia and hypertension have failed to produce ideal results due to the exclusion of chronic vascular inflammation. The … Read more