Pulmonary Hypertension

Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes

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Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes

On August 11, a communication from Mark Toshner at Papworth Royal Hospital was published in the Annals of the American Thoracic Society titled “Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes.” This multicenter study systematically reveals for the first time the complex association between C-reactive protein (CRP) and body mass index … Read more

Smooth Muscle Acid-Sensing Ion Channel 1a as a Therapeutic Target to Reverse Hypoxic Pulmonary Hypertension

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Smooth Muscle Acid-Sensing Ion Channel 1a as a Therapeutic Target to Reverse Hypoxic Pulmonary Hypertension

Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that simultaneously conducts Na+ and Ca2+. The activation of ASIC1a causes depolarization of the plasma membrane, stimulating Ca2+-dependent signaling pathways in various cell types, including vascular smooth muscle (SM) and endothelial cells (ECs). Previous studies have indicated that the increase in pulmonary vascular resistance … Read more