▉ Introduction Protein drugs have the potential to induce immunogenicity, which can affect efficacy and even endanger life. New paradigms in biotherapy, such as antibody-drug conjugates (ADC), fusion proteins, and pegylation carry non-native human protein sequences and/or structural motifs, which may increase their immunogenicity risk. Therefore, comprehensive risk assessment, strategies, and analysis are needed to … Read more
BioLegend is a company focused on biomedical research, offering a wide range of products, including but not limited to the following categories: flow cytometry-related products, stem cell research products, ELISA kits, Western blotting-related products, totalseq-related products, and many immunofluorescence-related products. Immunocytochemistry (ICC) is characterized by imaging cultured primary cells or cell lines. Immunohistochemistry (IHC) refers … Read more
Technical Terms are often confused with Immunofluorescence, Immunocytochemistry, and Immunohistochemistry. These three terms are often used interchangeably, which can lead to confusion when purchasing antibodies for microscopic experiments. Immunofluorescence (IF) Immunofluorescence (IF) refers to the detection method used (i.e., using fluorescent dyes to visualize the target of interest), regardless of the type of sample used. … Read more
Progress in Myositis-Specific Antibody Research 1. Clinical Significance of Myositis Antibodies: Helps in IIM classification; predicts IIM progression; aids in predicting complications of IIM; assists in determining treatment plans for IIM. Myositis antibody spectrum 10-year survival rate observation: anti-SRP > anti-HMGCR > anti-Mi-2 > anti-NXP-2 > anti-SAE > anti-TIF1-Υ > anti-MDA5. 2. NXP-2 Antibody: ① … Read more
Detection Items Myositis Antibody Spectrum 19 items (Mi-2, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, Ro-52, TIF1γ, MDA5, NXP2, HMGCR, SAE, OJ, KS, ZO, HA) Why Detect Myositis Antibody Spectrum? Idiopathic inflammatory myopathy (IIM) is a T cell-mediated autoimmune disease primarily attacking muscle fibers expressing major histocompatibility complex I (MHCI). The clinical manifestations are … Read more
▼ Click to Follow Our Official Account NXP2 Antibody Positive Juvenile Dermatomyositis Seven-year-old Xiao Yu (a pseudonym) started to show signs of not wanting to walk, unwilling to dress himself, and not wanting to wash his face or comb his hair around February 12 this year, constantly complaining of tiredness, leg pain, and lack of … Read more