Discussing Immunogenicity of ADCs
▉ Introduction Protein drugs have the potential to induce immunogenicity, which can affect efficacy and even endanger life. New paradigms in biotherapy, such as antibody-drug conjugates (ADC), fusion proteins, and pegylation carry non-native human protein sequences and/or structural motifs, which may increase their immunogenicity risk. Therefore, comprehensive risk assessment, strategies, and analysis are needed to … Read more
