nickel catalysis

J. Am. Chem. Soc.: Nickel-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions

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J. Am. Chem. Soc.: Nickel-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions

The nickel-catalyzed asymmetric reductive cross-coupling reaction can rapidly and modularly obtain enantiomer-rich building blocks from simple electrophilic precursors. The reductive coupling reaction can differentiate two different series of enantiomer-enriched products through a common organometallic intermediate, and this reaction has a particularly wide range of applications, but is underdeveloped. Here, the teams of Sarah E. Reisman … Read more

Synergistic Construction of Chiral Carbon Centers via Photocatalytic Nickel Catalysis

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Synergistic Construction of Chiral Carbon Centers via Photocatalytic Nickel Catalysis

Image source: J. Am. Chem. Soc.Introduction: The enantioselective alkyl-alkyl cross-coupling is a powerful and challenging strategy for constructing three-dimensional molecular structures, which hold significant value in organic chemistry and medicinal chemistry. Although radical-radical cross-coupling provides a feasible pathway to achieve this goal, controlling the cross-selectivity and enantioselectivity between two different alkyl radicals remains a significant … Read more