J. Am. Chem. Soc.: Nickel-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions
The nickel-catalyzed asymmetric reductive cross-coupling reaction can rapidly and modularly obtain enantiomer-rich building blocks from simple electrophilic precursors. The reductive coupling reaction can differentiate two different series of enantiomer-enriched products through a common organometallic intermediate, and this reaction has a particularly wide range of applications, but is underdeveloped. Here, the teams of Sarah E. Reisman … Read more