Synergistic Construction of Chiral Carbon Centers via Photocatalytic Nickel Catalysis

Synergistic Construction of Chiral Carbon Centers via Photocatalytic Nickel Catalysis

Image source: J. Am. Chem. Soc.Introduction: The enantioselective alkyl-alkyl cross-coupling is a powerful and challenging strategy for constructing three-dimensional molecular structures, which hold significant value in organic chemistry and medicinal chemistry. Although radical-radical cross-coupling provides a feasible pathway to achieve this goal, controlling the cross-selectivity and enantioselectivity between two different alkyl radicals remains a significant … Read more

Inexpensive Fe/Ni Enables Decarboxylative Cross-Coupling Reaction!

Inexpensive Fe/Ni Enables Decarboxylative Cross-Coupling Reaction!

Decarboxylative Cross-Coupling Enabled by Fe and Ni Metallaphotoredox CatalysisJ. Am. Chem. Soc. 2024, 146, 29551−29559Decarboxylative cross-coupling is a key reaction for constructing C(sp²)-C(sp³) bonds, with traditional methods relying on precious metals (such as Ir, Ru) as photocatalysts, which are costly and require harsh conditions. Iron (Fe), as a cheap, abundant, and environmentally friendly metal, can … Read more