Cross-Coupling

Asymmetric Decyanative Allylation of Tertiary Nitriles for the Construction of Quaternary Stereocenters

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Asymmetric Decyanative Allylation of Tertiary Nitriles for the Construction of Quaternary Stereocenters

Professor Wenbo Liu’s team at Wuhan University proposed a unique asymmetric decyanative allylation (ADCNA) platform, utilizing tertiary nitriles as precursors to construct quaternary chiral centers through the cleavage of C-CN bonds and C(sp3)-C(sp3) cross-coupling. This strategy demonstrates high efficiency and enantioselectivity under mild conditions, benefiting from newly developed chiral ligands. The method has broad applicability, … Read more

J. Am. Chem. Soc.: Nickel-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions

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J. Am. Chem. Soc.: Nickel-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions

The nickel-catalyzed asymmetric reductive cross-coupling reaction can rapidly and modularly obtain enantiomer-rich building blocks from simple electrophilic precursors. The reductive coupling reaction can differentiate two different series of enantiomer-enriched products through a common organometallic intermediate, and this reaction has a particularly wide range of applications, but is underdeveloped. Here, the teams of Sarah E. Reisman … Read more

Nickel-Catalyzed Double Decarboxylative Cross-Coupling of Aliphatic Carboxylic Acids

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Nickel-Catalyzed Double Decarboxylative Cross-Coupling of Aliphatic Carboxylic Acids

Abstract Recently, Professor David W. C. MacMillan, a 2021 Nobel Prize winner in Chemistry from Princeton University, reported a novel photonic/nickel cooperative catalysis strategy based on the double decarboxylative cross-coupling (SH2) reaction, which can be used to construct valuable C(sp3)-C(sp3) coupling products from aliphatic carboxylic acids. Detailed mechanistic studies indicate that this reaction involves an … Read more