Abstract:Lipid nanoparticles (LNPs) are lipid vesicles with a uniform lipid core that are widely used for the delivery of small molecule drugs and nucleic acids. They have recently gained significant attention due to their remarkable success as a delivery platform for COVID-19 mRNA vaccines. However, the application of mRNA-induced transient protein expression is not limited … Read more
The success of ADCs (Antibody-Drug Conjugates) relies on the continuous evolution of three generations of coupling technologies. From the “coarse” non-specific coupling to the “precise” gene-engineered modifications, and then to the “efficient” natural antibody modifications. Today, this iterative logic is providing key insights for breakthroughs in targeted delivery of antibody-conjugated LNPs (Ab-LNP).Ab-LNP requires precise coupling … Read more
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Recently, Professor Koen Raemdonck’s team at the University of Ghent, Belgium published a research paper titled “A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs” in The Journal of Controlled Release, Volume 350, 2022. The team utilized various cationic amphiphilic drugs as structural and functional components to prepare lipid nanoparticles (LNPs) … Read more