mRNA

Engineering Thiol-Mediated Uptake Lipid Nanoparticles: Breaking Endosomal Barriers for Enhanced mRNA Expression

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Engineering Thiol-Mediated Uptake Lipid Nanoparticles: Breaking Endosomal Barriers for Enhanced mRNA Expression

Hello everyone, today I would like to share an important research achievement published by Professors Li Jingying and Yang Huanghao from Fuzhou University in the Journal of the American Chemical Society (JACS). The paper is titled: “Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery”. This work focuses on the current core … Read more

In-Depth Analysis of How Lipid Nanoparticles (LNP) Deliver RNA Drugs

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In-Depth Analysis of How Lipid Nanoparticles (LNP) Deliver RNA Drugs

Abstract:Lipid nanoparticles (LNPs) are lipid vesicles with a uniform lipid core that are widely used for the delivery of small molecule drugs and nucleic acids. They have recently gained significant attention due to their remarkable success as a delivery platform for COVID-19 mRNA vaccines. However, the application of mRNA-induced transient protein expression is not limited … Read more

Repurposing Cationic Amphiphilic Drugs for mRNA Delivery

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Repurposing Cationic Amphiphilic Drugs for mRNA Delivery

Recently, Professor Koen Raemdonck’s team at the University of Ghent, Belgium published a research paper titled “A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs” in The Journal of Controlled Release, Volume 350, 2022. The team utilized various cationic amphiphilic drugs as structural and functional components to prepare lipid nanoparticles (LNPs) … Read more