Lipid Nanoparticles

Engineering Thiol-Mediated Uptake Lipid Nanoparticles: Breaking Endosomal Barriers for Enhanced mRNA Expression

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Engineering Thiol-Mediated Uptake Lipid Nanoparticles: Breaking Endosomal Barriers for Enhanced mRNA Expression

Hello everyone, today I would like to share an important research achievement published by Professors Li Jingying and Yang Huanghao from Fuzhou University in the Journal of the American Chemical Society (JACS). The paper is titled: “Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery”. This work focuses on the current core … Read more

The Continuous Evolution of LNPs

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The Continuous Evolution of LNPs

Research Background Lipid nanoparticles (LNPs) are an ideal carrier for delivering various drugs with poor in vivo stability, and they are widely used in drug development strategies for proteins, nucleic acids, and more. The launch of the world’s first siRNA drug, Patisiran, marked the transition of LNPs from laboratory research to clinical application, further highlighting … Read more

Literature Sharing | J. Am. Chem. Soc | Ultrasound-Activated Lipid Nanoplatform for Region-Specific Innate Immune Stimulation and Cancer mRNA Vaccination

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Literature Sharing | J. Am. Chem. Soc | Ultrasound-Activated Lipid Nanoplatform for Region-Specific Innate Immune Stimulation and Cancer mRNA Vaccination

The Shanghai Institute of Materia Medica, Chinese Academy of Sciences, in collaboration with Researcher Hai Jun and Professor Xu Zhi’ai from the School of Chemistry and Molecular Engineering at East China Normal University, has developed a novel LNP component—ultrasound adjuvant lipids, which endow clinically approved LNP formulations with region-specific adjuvant properties. mRNA vaccines based on … Read more

Understanding The Mechanism of Immune Response Triggered by Different Lipid Components in Lipid Nanoparticles (LNP)

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Understanding The Mechanism of Immune Response Triggered by Different Lipid Components in Lipid Nanoparticles (LNP)

Note: This article does not constitute any investment opinion or advice, and should be based on official/company announcements; it is only intended for the introduction of medical and health-related drugs and does not represent treatment recommendations (if involved), nor does it represent the position of Yao Hai Biotechnology. Any reproduction of this article requires authorization. … Read more