Reports on CNS Medicine and Biology Publications by Chinese Scholars in 2025
— Tracking Academic Frontiers —
The journals Cell (USA), Nature (UK), and Science (USA) are internationally recognized as the top three scientific journals with the highest academic reputation, and papers published in these journals are referred to as CNS papers.
From January to February 2025, scholars from mainland China published a total of 72 papers in these three journals as the first completing unit (only counting Research Articles and Reviews in Cell, Articles and Reviews in Nature, and Research Articles, Reviews, and Reports in Science). Among them, Cell published 19 papers, Nature published 34 papers, and Science published 19 papers.
We have compiled the articles related to medicine and biology published by authors from mainland China in CNS.
#01
Medical and Biological Publications in Cell
From January to February 2025, Cell published a total of 67 Research Articles and Reviews. Among them, 15 papers related to medicine and biology were published by authors from mainland China, all of which are Research Articles. The detailed information is as follows:
1.Wen X, Shang P, Chen H, et al. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4[J].
Cell, 2025, 188(3): 653-670.
Title: Evolutionary Study and Structural Basis of Proton Sensing by Mouse GPR4 and African Clawed Frog GPR4
First Completing Unit: Shandong University
2.Hu B, He R, Pang K, et al. High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning[J].
Cell, 2025, 188(3): 734-748.
Title: High-resolution Spatially Resolved Proteomics of Complex Tissues Based on Microfluidics and Transfer Learning
First Completing Unit: Institute of Zoology, Chinese Academy of Sciences
3.Li K, Yu P, Zheng Q, et al. Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution[J].
Cell, 2025, 188(3): 796-813.
Title: Spatiotemporal and Genetic Cell Lineage Tracing of Endodermal Organogenesis at Single-cell Resolution
First Completing Unit: Peking University
4.Zhu W, Meng J, Li Y, et al. Comparative proteomic landscapes elucidate human preimplantation development and failure[J].
Cell, 2025, 188(3): 814-831.
Title: Comparative Proteomic Landscapes Elucidate Mechanisms of Human Preimplantation Development and Failure
First Completing Unit: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
5.Song H, Hao T, Han P, et al. Receptor binding, structure, and tissue tropism of cattle-infecting H5N1 avian influenza virus hemagglutinin[J].
Cell, 2025, 188(4): 919-929.
Title: Study on Receptor Binding, Structure, and Tissue Tropism of H5N1 Avian Influenza Virus Hemagglutinin Infecting Cattle
First Completing Unit: Capital Medical University
6.Ding M, Wang D, Chen H, et al. A biophysical basis for the spreading behavior and limited diffusion of Xist[J].
Cell, 2025, 188(4): 978-997.
Title: Biophysical Basis for the Spreading Behavior and Limited Diffusion of Xist RNA
First Completing Unit: Tsinghua University
7.Zhong L, Gan L, Wang B, et al. Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients[J].
Cell, 2025, 188(4): 1119-1136.
Title: Hyperacute Rejection-engineered Oncolytic Virus for Interventional Clinical Trials in Refractory Cancer Patients
First Completing Unit: Guangxi Medical University
8.Zhang M, Feng J, Xie C, et al. Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus[J].
Cell, 2025, 188(5): 1198-1207.
Title: Assembly and Architecture of Endogenous NMDA Receptors in Adult Cerebral Cortex and Hippocampus
First Completing Unit: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
9.Xing L, Liu Z, Wang X, et al. Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target[J].
Cell, 2025, 188(5): 1297-1314.
Title: Early Fusion Intermediate of Coronavirus Spike Using ACE2 as an Antiviral Target
First Completing Unit: Fudan University
10.Rational multienzyme architecture design with iMARS[J]. Cell, 2025, 188(5): 1349-1362.
Title: Rational Multienzyme Architecture Design Based on iMARS
First Completing Unit: Shanghai Jiao Tong University
11.Yang Z, Ping Y, Wang M, et al. Identification, structure, and agonist design of an androgen membrane receptor[J].
Cell, 2025, 188(6): 1589-1604.
Title: Identification, Structure, and Agonist Design of a Novel Androgen Membrane Receptor
First Completing Unit: Shandong University
12.Ma C, Liu C, Park Y, et al. Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses[J].
Cell, 2025, 188(6): 1693-1710.
Title: Multiple Independent Evolutionary Events of ACE2 Usage in MERS-related Coronaviruses
First Completing Unit: Wuhan University
13.Chen J, Zhang W, Li Y, et al. Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor[J].
Cell, 2025, 188(6): 1729-1742.
Title: Novel Bat HKU5 Coronavirus Can Utilize Human ACE2 Receptor for Cell Entry
First Completing Unit: Wuhan Institute of Virology, Chinese Academy of Sciences
14.6A-dependent mRNA mLan Y, Xia Z, Shao Q, et al. Synonymous mutations promote tumorigenesis by disrupting metabolism[J/OL].
Cell, 2025, (2025-02-13)[2025-03-20].
https://doi.org/10.1016/j.cell.2025.01.026.
Title: Synonymous Mutations Promote Tumorigenesis by Disrupting m6A-dependent mRNA Metabolism
First Completing Unit: Xihu Laboratory
15.Ou X, Ma C, Sun D, et al. SecY translocon chaperones protein folding during membrane protein insertion[J/OL].
Cell, 2025, (2025-02-19)[2025-03-20].
https://doi.org/10.1016/j.cell.2025.01.037.
Title: SecY Translocon Functions as a Molecular Chaperone During Membrane Protein Insertion
First Completing Unit: Peking University
#02
Publications in Nature
From January to February 2025, Nature published a total of 270 Articles and Reviews. Among them, 11 papers related to medicine and biology were published by authors from mainland China, including 10 Articles and 1 Review. The detailed information is as follows:
1.Lan F, Li J, Miao W, et al. GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases[J].
Nature, 2025, 638(8050): 490-498.
Title: GZMK-expressing CD8+ T Cells Promote Recurrent Airway Inflammatory Diseases
First Completing Unit: Capital Medical University
2.Xie F, Zhou X, Ran Y, et al. Targeting FOXM1 condensates reduces breast tumour growth and metastasis[J].
Nature, 2025, 638(8052): 1112-1121.
Title: Targeting FOXM1 Condensates Reduces Breast Tumor Growth and Metastasis
First Completing Unit: Suzhou University
3.Li Z, Xu Q, Zhong J, et al. Structural insights into RNA cleavage by PIWI Argonaute[J].
Nature, 2025, 639(8053): 250-259.
Title: Structural Insights into RNA Cleavage by PIWI Argonaute Protein
First Completing Unit: Westlake University
4.Huang S, Wang J, Song R, et al. Balanced plant helper NLR activation by a modified host protein complex[J].
Nature, 2025, 639(8054): 447-455.
Title: Balanced Activation of Plant Helper NLR by a Modified Host Protein Complex
First Completing Unit: Westlake University
5.Zhang X, Zhang X, Ren J, et al. Precise modelling of mitochondrial diseases using optimized mitoBEs[J].
Nature, 2025, 639(8055): 735-745.
Title: Successful Establishment of Precise Mitochondrial Disease Models Using Optimized mitoBEs
First Completing Unit: Changping Laboratory
6.Tang X, Hu Z, Ding J, et al. In vitro reconstitution of meiotic DNA double-strand-break formation[J].
Nature, 2025, 639(8055): 800-807.
Title: In Vitro Reconstitution of Meiotic DNA Double-Strand Break Formation
First Completing Unit: Excellence Innovation Center for Molecular Cell Science, Chinese Academy of Sciences
7.Zhu J, Liang M, Sun K, et al. De novo design of transmembrane fluorescence-activating proteins[J/OL].
Nature, 2025, (2025-02-19)[2025-03-20].
https://doi.org/10.1038/s41586-025-08598-8.
Title: De Novo Design of Transmembrane Fluorescence-Activating Proteins
First Completing Unit: Zhejiang University
8.Zhao H, Shu L, Qin S, et al. Extensive mutual influences of SMC complexes shape 3D genome folding[J/OL].
Nature, 2025, (2025-02-26)[2025-03-20].
https://doi.org/10.1038/s41586-025-08638-3.
Title: Extensive Mutual Influences of SMC Complexes Shape 3D Genome Folding
First Completing Unit: Shenzhen Bay Laboratory
9.Liu M, Yue Y, Chen X, et al. Genome-coverage single-cell histone modifications for embryo lineage tracing[J/OL].
Nature, 2025, (2025-02-26)[2025-03-20].
https://doi.org/10.1038/s41586-025-08656-1.
Title: Comprehensive Single-Cell Histone Modifications Dynamic Analysis for Embryonic Development Epigenetic Lineage
First Completing Unit: Peking University
10.Zhang S, Xu N, Fu L, et al. Integrated analysis of the complete sequence of a macaque genome[J/OL].
Nature, 2025, (2025-02-26)[2025-03-20].
https://doi.org/10.1038/s41586-025-08596-w.
Title: Integrated Analysis of the Complete Sequence of a Macaque Genome
First Completing Unit: Shanghai Jiao Tong University
1 Review:
Guo T, Steen J A, Mann M. Mass-spectrometry-based proteomics: from single cells to clinical applications[J].
Nature, 2025, 638(8052): 901-911.
Title: Mass-Spectrometry-Based Proteomics: From Single Cells to Clinical Applications
First Completing Unit: Westlake University
#03
Publications in Science
From January to February 2025, Science published a total of 144 Research Articles, Reviews, and Reports. Among them, 5 papers related to medicine and biology were published by authors from mainland China, all of which are Research Articles. The detailed information is as follows:
1.Wu K, Xu Q, Liu Y, et al. Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease[J].
Science, 2025, 387(6736): 892-900.
Title: Neuronal FAM171A2 Mediates α-Synuclein Fibril Uptake and Drives Parkinson’s Disease
First Completing Unit: Fudan University
2.Wei A, Zhao A, Zheng C, et al. Sexually dimorphic dopaminergic circuits determine sex preference[J/OL].
Science, 2025, 387(6730)(2025-01-10)[2025-03-20].
https://www.science.org/doi/10.1126/science.adq7001.
Title: Sexually Dimorphic Dopaminergic Circuits Determine Sex Preference
First Completing Unit: Xi’an Jiaotong University
3.Ding K, Zhang Z, Han Z, et al. Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling[J/OL].
Science, 2025, 387(6737)(2025-02-28)[2025-03-20].
https://www.science.org/doi/10.1126/science.adp4120.
Title: Liver ALKBH5 Independently Regulates Glucose and Lipid Homeostasis Through GCGR and mTORC1 Signaling
First Completing Unit: Harbin Institute of Technology
4.Sun Y, Ren M, Zhang Y, et al. Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival[J/OL].
Science, 2025, (2025-01-30)[2025-03-20].
https://www.science.org/doi/10.1126/science.ado4930.
Title: Casz1 is Required for Both Inner Hair Cell Fate Stabilization and Outer Hair Cell Survival
First Completing Unit: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
5.Zeng Z, Hu Z, Zhao R, et al. Base-modified nucleotides mediate immune signaling in bacteria[J/OL].
Science, 2025, (2025-02-20)[2025-03-20].
https://www.science.org/doi/10.1126/science.ads6055.
Title: Base-modified Nucleotides Mediate Immune Signaling in Bacteria
First Completing Unit: Huazhong Agricultural University
— END —
Images and text by the Learning and Research Support DepartmentEdited by Dai AoyingInitial Review by Su YujingRe-review by Bi MengruFinal Review by Li Yuping