â–ŽArmstrong
The 2025 American Association for Cancer Research (AACR) Annual Meeting will be held from April 25-30 in Chicago, USA. Recently, the conference abstracts have been released, showcasing a significant presence of Chinese innovations. In the field of ADCs, the majority of reports come from Chinese pharmaceutical companies, with nearly 100 innovative ADCs covering various technological routes and targets, truly leading the innovation frontier of ADCs.
Bispecific ADCs are currently one of the hottest directions in the ADC field, with companies such as BaiLisiKang, BaiAoSaiTu, BoRui Biotech, ChengFan Pharma, DuoXi Biotech, HengRui Pharma, JiShi Pharma, JinSai Pharma, KangNingJieRui, KangYuan BoChuang, LianJin Biotech, QiDe Pharma, ShiYao Group, TuoJi Biotech, XianSheng Pharma, XinDa Biotech, YingEn Biotech, and Affinity Biotech all making strides in this area.
Bispecific toxin ADCs are also coming to the forefront, with KangHeng Pharma and Affinity Biotech developing bispecific toxin ADCs. KangHeng Pharma’s KH815 is the world’s first bispecific toxin ADC new drug to enter clinical stages. The two payloads are TOP1i and RAN POL2i, which simultaneously inhibit RNA synthesis and induce DNA double-strand breaks.
KangNingJieRui has further developed a bispecific bispecific toxin ADC, namely the EGFR/HER3 bispecific toxin ADC new drug JSKN021.
The traditional concept of ADCs is that toxins are released after antibodies bind to receptors and mediate endocytosis. DXd-ADC has demonstrated the significant role of the bystander effect, and YiLian Biotech has further developed a non-endocytosed ADC that targets free VEGF, releasing toxins through tumor microenvironment-specific enzymes, further expanding the application space of ADC drugs.
WeiliZhiBo has developed the first TCE ADC, namely the DLL3/CD3 ADC new drug LBL-058, which is formed by coupling DLL3/CD3 bispecific antibodies with TOP1i, synergizing T-cell killing and payload cytotoxic effects. Although TCE has begun to break through solid tumors at a few targets, the design of TCE-ADC undoubtedly provides a new enhanced design approach for overcoming solid tumors.
Conclusion
From this AACR meeting, it is evident that Chinese ADCs are leading the innovation frontier in terms of both quantity and differentiated design. New target ADCs, new target combination bispecific ADCs, bispecific toxin ADCs, PDCs, TCE-ADCs, non-endocytosed ADCs, etc., along with self-immune ADCs (YingEn Biotech has already entered clinical stages) not covered in the AACR meeting, are all noteworthy. In the coming years, the clinical breakthroughs and international transactions of domestic ADCs remain a focal point of the industry.
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