Stereochemistry

Vicinal Stereocenter Construction via α-Boryl Carbanions from Borylated Cyclopropanes

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Vicinal Stereocenter Construction via α-Boryl Carbanions from Borylated Cyclopropanes

The Technion – Israel Institute of Technology Professor Ilan Marek’s team utilized α-boryl carbanion intermediates as a platform for stereochemical generation, exploring the complex behavior of α-boryl carbanions generated from various cyclopropyl boronic methyl iodides in selective ring-opening and electrophilic reactions, conducting a series of highly stereoselective nucleophilic substitution reactions to construct vicinal stereocenters. Abstract … Read more

Cu-Catalyzed Asymmetric Nucleophilic Opening of Tetrasubstituted DAC

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Cu-Catalyzed Asymmetric Nucleophilic Opening of Tetrasubstituted DAC

Researchers have found that the asymmetric catalytic transformation of donor–acceptor cyclopropanes (DAC) can construct various types of stereochemically enriched molecules, which is highly valuable, and this strategy is very powerful. However, how to use 1,1,2,2-tetrasubstituted DAC cyclopropanes to synthesize products that modify quaternary carbon stereocenters remains an unresolved challenge.In this regard, Researcher Fang Xinqiang from … Read more

Synthesis of Stereocontrolled Azetidine Library via Strain-Release Functionalization of 1-Azabicyclobutanes

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Synthesis of Stereocontrolled Azetidine Library via Strain-Release Functionalization of 1-Azabicyclobutanes

Image source: J. Am. Chem. Soc.Introduction: Professors Benjamin F. Cravatt and Phil S. Baran developed a concise, modular, and programmable synthetic strategy based on strain-release functionalization reactions for constructing structurally complex stereopure nitrogen-containing bicyclic compounds known as Azetidine. This synthetic method allows for the parallel preparation of nitrogen-containing bicyclic compounds with defined stereostructures, which is … Read more