Nitrogen-containing compounds

Efficient Synthesis of N-Alkyl or N-Aryl Nitrogen-Containing Propanes via α and β Nucleophilic Additions

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Efficient Synthesis of N-Alkyl or N-Aryl Nitrogen-Containing Propanes via α and β Nucleophilic Additions

The team of Wenbo Liu and Quanbin Jiang from Sun Yat-sen University achieved the efficient transformation of conjugated hydroxamic acids into redox-neutral nitrogen-containing propanes through nucleophilic α and β addition strategies. It is noteworthy that electron-rich anilines, such asN,N–dimethylaminoaniline and4-methoxyaniline, can directly serve as nitrogen atom donors in the nitrogenation process. The success of this … Read more

Synthesis of Stereocontrolled Azetidine Library via Strain-Release Functionalization of 1-Azabicyclobutanes

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Synthesis of Stereocontrolled Azetidine Library via Strain-Release Functionalization of 1-Azabicyclobutanes

Image source: J. Am. Chem. Soc.Introduction: Professors Benjamin F. Cravatt and Phil S. Baran developed a concise, modular, and programmable synthetic strategy based on strain-release functionalization reactions for constructing structurally complex stereopure nitrogen-containing bicyclic compounds known as Azetidine. This synthetic method allows for the parallel preparation of nitrogen-containing bicyclic compounds with defined stereostructures, which is … Read more