Synthesis of Stereocontrolled Azetidine Library via Strain-Release Functionalization of 1-Azabicyclobutanes
Image source: J. Am. Chem. Soc.Introduction: Professors Benjamin F. Cravatt and Phil S. Baran developed a concise, modular, and programmable synthetic strategy based on strain-release functionalization reactions for constructing structurally complex stereopure nitrogen-containing bicyclic compounds known as Azetidine. This synthetic method allows for the parallel preparation of nitrogen-containing bicyclic compounds with defined stereostructures, which is … Read more