glycosylation

Thiocrown Ether: Reversing SN1 to SN2 Pathways in 1,2-cis Phosphoryl Glycosylation

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Thiocrown Ether: Reversing SN1 to SN2 Pathways in 1,2-cis Phosphoryl Glycosylation

Phosphoryl glycosides are a class of complex carbohydrates that are ubiquitous and critically important in biological systems. Given their significant roles in various physiological and pathophysiological processes, the synthesis of phosphoryl glycosides has become a central scientific issue in glycoscience. However, their preparation faces two major challenges: achieving high stereoselectivity in phosphorylated glycosides and maintaining … Read more

Unlocking Chemical Space: Electrochemically Driven Synthesis of Glycosyl Bicyclo[1.1.1]pentane Frameworks

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Unlocking Chemical Space: Electrochemically Driven Synthesis of Glycosyl Bicyclo[1.1.1]pentane Frameworks

Image source: J. Am. Chem. Soc.Introduction: In the past decade, [1.1.1]propellane derivatives (BCPs) have provided a unique three-dimensional spatial structure for drug chemistry as superior bioelectronic scaffolds. Meanwhile, glycosyl derivatives play a crucial role in chemical biology and drug discovery due to their widespread presence in bioactive molecules. However, the potential of [1.1.1]propellane as a … Read more

Literature Sharing | J. Am. Chem. Soc. | Functionalized Boron-Containing Pentacyclic Sialic Acid Probes for High-Fidelity Fluorescence Imaging of Cancer Tissues

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Literature Sharing | J. Am. Chem. Soc. | Functionalized Boron-Containing Pentacyclic Sialic Acid Probes for High-Fidelity Fluorescence Imaging of Cancer Tissues

The team led by Professor Young-Tae Chang at Pohang University of Science and Technology in South Korea has developed a fluorescence probe (SLY) based on boron-doped heteroaromatic compounds for the specific recognition of sialylated Lewis antigens (sLex and sLea) that are overexpressed on the cell surface, achieving high-fidelity fluorescence imaging of cancer regions at both … Read more