C-N Coupling of Brominated Heteroaromatic Compounds Catalyzed by Ni

C-N Coupling of Brominated Heteroaromatic Compounds Catalyzed by Ni

[OL]Ni Catalyzed C-N Coupling of Brominated Heteroaromatic Compounds Introduction Constructing C-N bonds is generally more challenging than constructing C-C bonds. After all, the Buchwald-Hartwig coupling is not effective for all substrates, especially for certain heterocycles and substrates containing active hydrogens, which can easily complex with the catalyst and lead to no reaction. In contrast, usingSuzuki … Read more

Inexpensive Fe/Ni Enables Decarboxylative Cross-Coupling Reaction!

Inexpensive Fe/Ni Enables Decarboxylative Cross-Coupling Reaction!

Decarboxylative Cross-Coupling Enabled by Fe and Ni Metallaphotoredox CatalysisJ. Am. Chem. Soc. 2024, 146, 29551−29559Decarboxylative cross-coupling is a key reaction for constructing C(sp²)-C(sp³) bonds, with traditional methods relying on precious metals (such as Ir, Ru) as photocatalysts, which are costly and require harsh conditions. Iron (Fe), as a cheap, abundant, and environmentally friendly metal, can … Read more