Decarboxylation

Nickel-Catalyzed Double Decarboxylative Cross-Coupling of Aliphatic Carboxylic Acids

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Nickel-Catalyzed Double Decarboxylative Cross-Coupling of Aliphatic Carboxylic Acids

Abstract Recently, Professor David W. C. MacMillan, a 2021 Nobel Prize winner in Chemistry from Princeton University, reported a novel photonic/nickel cooperative catalysis strategy based on the double decarboxylative cross-coupling (SH2) reaction, which can be used to construct valuable C(sp3)-C(sp3) coupling products from aliphatic carboxylic acids. Detailed mechanistic studies indicate that this reaction involves an … Read more

Unlocking Chromium Decarboxylative Ligand-to-Metal Charge Transfer: Efficient and Redox-Neutral Allylation of Aldehydes Using Carboxylic Acids

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Unlocking Chromium Decarboxylative Ligand-to-Metal Charge Transfer: Efficient and Redox-Neutral Allylation of Aldehydes Using Carboxylic Acids

Recently, Professor Alexander W. Schuppe’s team from Vanderbilt University reported in J. Am. Chem. Soc. the decarboxylative ligand-to-metal charge transfer (LMCT) reaction of photoinduced Cr (III) carboxylate complexes, applying it to the stereoselective Nozaki-Hiyama-Kishi (NHK) allylation reaction. This method directly utilizes carboxylic acids without the need for external redox reagents, achieving good yields and high … Read more

New Breakthrough in Photocatalysis! Direct Conversion of Carboxylic Acids to Radicals, Adding a New Tool for Green Chemistry, Goodbye to Heavy Metals!

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New Breakthrough in Photocatalysis! Direct Conversion of Carboxylic Acids to Radicals, Adding a New Tool for Green Chemistry, Goodbye to Heavy Metals!

Image source: J. Am. Chem. Soc.Introduction: The carboxyl radical, as a highly reactive intermediate, is expected to open unique transformation pathways for radical chemistry. However, the current methods for directly generating carboxyl radicals from carboxylic acids mostly rely on environmentally unfriendly processes, and their applications are mainly limited to decarboxylation functionalization reactions. This study proposes … Read more