Asymmetric Decyanative Allylation of Tertiary Nitriles for the Construction of Quaternary Stereocenters
Professor Wenbo Liu’s team at Wuhan University proposed a unique asymmetric decyanative allylation (ADCNA) platform, utilizing tertiary nitriles as precursors to construct quaternary chiral centers through the cleavage of C-CN bonds and C(sp3)-C(sp3) cross-coupling. This strategy demonstrates high efficiency and enantioselectivity under mild conditions, benefiting from newly developed chiral ligands. The method has broad applicability, … Read more